Ignite Creation Date:
2024-05-06 @ 3:23 PM
Last Modification Date:
2024-10-26 @ 1:48 PM
Study NCT ID:
NCT04614701
Status:
WITHDRAWN
Last Update Posted:
2022-06-27
First Post:
2020-10-21
Brief Title:
Correlation of Carotid Flow Time and Cardiac Output
Sponsor:
St Boniface Hospital
Organization:
St Boniface Hospital
Study Overview
Official Title:
Correlation of Carotid Flow Time and Cardiac Output With Preload Augmentation in Patients With COVID-19
Status:
WITHDRAWN
Status Verified Date:
2022-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
The co and principal investigator due to limited resources and timing have decided to withdrawal the study and close
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Assessment of common carotid artery flow is more easily done and can be taught more broadly than transthoracic echocardiography providing a greater number of clinicians a tool to assess volume responsiveness These assessments are of great importance to patients with COVID-19 who often present with hypotension requiring fluids which must be balanced against limiting fluid administration to minimize pulmonary edema
Detailed Description:
Optimizing volume status for patients in shock is of critical importance to their outcomes both in the provision of helpful and avoidance of harmful fluid volumes As such much work has been done to develop and assess measures of volume responsiveness that is tests that indicate whether additional fluid administration will increase cardiac output by at least 10 The passive leg raise PLR providing a reversible auto-bolus has been demonstrated to be the most predictive assessment of fluid responsiveness
Recent studies of changes in carotid artery blood flow suggest it can be used as a surrogate for changes in cardiac output with moderate reliability This has been assessed in several populations with anticipated changes in volume status eg beforeafter blood donation and more recently assessed by Sidor et al against several preload augmenting maneuvers Interestingly while decreasing preload resulted in a decrease in cardiac output and systolic carotid blood flow it did not result in a decrease in corrected carotid flow time although a PLR produced an expected increase in all measures
In our study we seek to validate these results questioning if there is a lower limit of corrected carotid flow time that de-couples the relationship between carotid systolic flow and corrected carotid flow time
Recent studies of changes in carotid artery blood flow suggest it can be used as a surrogate for changes in cardiac output with moderate reliability This has been assessed in several populations with anticipated changes in volume status eg beforeafter blood donation and more recently assessed by Sidor et al against several preload augmenting maneuvers Interestingly while decreasing preload resulted in a decrease in cardiac output and systolic carotid blood flow it did not result in a decrease in corrected carotid flow time although a PLR produced an expected increase in all measures
In our study we seek to validate these results questioning if there is a lower limit of corrected carotid flow time that de-couples the relationship between carotid systolic flow and corrected carotid flow time
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None