Ignite Creation Date:
2024-05-05 @ 11:19 AM
Last Modification Date:
2024-10-26 @ 9:01 AM
Study NCT ID:
NCT00000290
Status:
COMPLETED
Last Update Posted:
2017-01-12
First Post:
1999-09-20
Brief Title:
Stress Hormones and Human Cocaine Use - 7
Sponsor:
National Institute on Drug Abuse NIDA
Organization:
National Institute on Drug Abuse NIDA
Study Overview
Official Title:
Stress Hormones and Human Cocaine Use
Status:
COMPLETED
Status Verified Date:
2016-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to determine the HPA axis and adrenergic system activation in response to cocaine administration
Detailed Description:
The goal of this study was to investigate the role of sympathetic-adrenal medullary SAM and hy0pothalamo-pituitary-adrenal HPA systems in mediating the addictive effects of cocaine A toal of 6 male subjects were enrolled for this 5 day inpatient study Subjects were assigned to either cocaine 32mg 70kg iv or placebo saline iv treatment during the first experimental sessions and were crossed over to the alternative treatment during the second experimental session Endpoints that were followed during the experimental sessions included neuroendocrine serum epinephrine norepinephrine and cortisol levels physological heart rateblood pressure EKG and subjective measures Beck Depression Inventory Craving Questionnaire We hypothesized that cocaine administration would lead to increased blood levels of norpinephrine epinephrine and cortisol in cocaine dependent subjects
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| P50-09259-7 | None | None | None |