Ignite Creation Date:
2024-05-06 @ 3:22 PM
Last Modification Date:
2024-10-26 @ 1:48 PM
Study NCT ID:
NCT04614753
Status:
COMPLETED
Last Update Posted:
2023-10-03
First Post:
2020-10-20
Brief Title:
Dealcoholized Muscadine Wine and Skin Health in Women
Sponsor:
University of Florida
Organization:
University of Florida
Study Overview
Official Title:
A Clinical Trial to Determine the Activity of Dealcoholized Muscadine Wine to Alleviate Oxidative Stress Inflammation Skin Photoaging and Alter the Gut Microbiome in Women 40-67
Status:
COMPLETED
Status Verified Date:
2024-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The objective of this clinical trial is to determine the activity of dealcoholized muscadine wine to alleviate oxidative stress inflammation skin photoaging and alter gut microbiome in women 40-67 years of age The investigators hypothesize that dealcoholized muscadine wine daily for 42 days will significantly alleviate oxidative stress inflammation skin photoaging and alter the gut microbiome in women compared to drinking sugar water
Detailed Description:
Aging of the skin is characterized by wrinkling sagging and laxity About 80 of facial skin aging is classified as extrinsic or photoaging because it results from exposure to UV light of the sun that causes oxidative stress The remaining 20 of facial aging is the intrinsic type which is partially caused by the accumulation of proteins that are modified by reactive carbonyls in a reaction known as protein glycation Aging also shifts the composition of the gut microbiome in at least 35 genera towards an unhealthy state of dysbiosis
Previous studies showed that muscadine polyphenols inhibited protein glycation under a simulated physiological condition Additional experiments using cell culture and mice showed that dealcoholized muscadine wine alleviated inflammation and protected against dysbiosis in the gut The objective of this research is to confirm the health benefits of muscadine wine polyphenols in a clinical trial The investigators hypothesize that dealcoholized muscadine wine consumption in women 40-65 years old will alleviate skin photoaging and skin conditions by decreasing oxidative stress and inflammation It is also expected to improve the composition of the gut microbiome
Previous studies showed that muscadine polyphenols inhibited protein glycation under a simulated physiological condition Additional experiments using cell culture and mice showed that dealcoholized muscadine wine alleviated inflammation and protected against dysbiosis in the gut The objective of this research is to confirm the health benefits of muscadine wine polyphenols in a clinical trial The investigators hypothesize that dealcoholized muscadine wine consumption in women 40-65 years old will alleviate skin photoaging and skin conditions by decreasing oxidative stress and inflammation It is also expected to improve the composition of the gut microbiome
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None