Ignite Creation Date:
2024-05-05 @ 11:19 AM
Last Modification Date:
2024-10-26 @ 9:04 AM
Study NCT ID:
NCT00005138
Status:
COMPLETED
Last Update Posted:
2016-05-13
First Post:
2000-05-25
Brief Title:
High Blood Pressure in the Young
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Heart Lung and Blood Institute NHLBI
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2000-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To continue a longitudinal study of blood pressure and blood pressure correlates in a population of 1140 young adults first seen in 1973 as adolescents aged 14-19 years
Detailed Description:
BACKGROUND
This study was funded in response to a Request for Application issued in 1975 on High Blood Pressure in the Young The program on High Blood Pressure in the Young grew out of an awareness that adult hypertension might have its origins in adolescence or even in childhood or infancy In 1975 NHLBI was supporting little research except for the Specialized Centers of Research in identifying the precursors of high blood pressure operating at an early age Sixteen grants were funded through the program The program was concluded in 1978 but Dr Kotchens grant was renewed as a regular research grant A second population group was followed in the grant period From an original population of 409 pregnant nulliparous adolescents aged 12-18 who had enrolled in the University of Kentucky Young Mothers Program between 1971-1974 70 were diagnosed as having hypertension during the third trimester of pregnancy These 70 women plus a control group of 54 normotensive women from the same population were studied as were their children Blood pressures were measured in young mothers at 3-6 years and at 6-9 years after their first pregnancy Women with a history of hypertension during pregnancy were heavier maintained higher blood pressure and had a greater incidence of hypertension in subsequent pregnancies At the second follow-up systolic blood pressure and body weight of male children born to hypertensive women were greater than those in males born to normotensive women Blood pressures of female children of the two groups of mothers did not differ
DESIGN NARRATIVE
In 1973 standardized blood pressure height and weight were measured in all 14-19 year old students of Bourbon County High School in Kentucky Additional information collected included age date of birth sex and race In 1978 a five year follow-up study was undertaken of all adolescents 14-15 years old at the time of the initial survey and of selected 16-19 year olds who were in the high intermediate and low ranges of the blood pressure distributions Follow-up measurements included weight height and blood pressure in all subjects and sodium excretion serum cholesterol glucose triglycerides exercise and uric acid concentrations electrocardiograms and echocardiograms in the older group In 1984 the follow-up also included information on socioeconomic variables medical and family histories smoking exercise life events coronary-prone behavior and anxiety Plasma renin activity and plasma aldosterone were measured before and after treadmill exercise in those young adults with relatively high and relatively low blood pressures to determine if the renin-aldosterone axis is suppressed before the appearance of hypertension Studies were continued on physiologic psychosocial and behavioral risk factors for hypertension age-related trends in cardiovascular risk factors over time correlates of elevated blood pressure and the early cardiac consequences of high blood pressure
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
This study was funded in response to a Request for Application issued in 1975 on High Blood Pressure in the Young The program on High Blood Pressure in the Young grew out of an awareness that adult hypertension might have its origins in adolescence or even in childhood or infancy In 1975 NHLBI was supporting little research except for the Specialized Centers of Research in identifying the precursors of high blood pressure operating at an early age Sixteen grants were funded through the program The program was concluded in 1978 but Dr Kotchens grant was renewed as a regular research grant A second population group was followed in the grant period From an original population of 409 pregnant nulliparous adolescents aged 12-18 who had enrolled in the University of Kentucky Young Mothers Program between 1971-1974 70 were diagnosed as having hypertension during the third trimester of pregnancy These 70 women plus a control group of 54 normotensive women from the same population were studied as were their children Blood pressures were measured in young mothers at 3-6 years and at 6-9 years after their first pregnancy Women with a history of hypertension during pregnancy were heavier maintained higher blood pressure and had a greater incidence of hypertension in subsequent pregnancies At the second follow-up systolic blood pressure and body weight of male children born to hypertensive women were greater than those in males born to normotensive women Blood pressures of female children of the two groups of mothers did not differ
DESIGN NARRATIVE
In 1973 standardized blood pressure height and weight were measured in all 14-19 year old students of Bourbon County High School in Kentucky Additional information collected included age date of birth sex and race In 1978 a five year follow-up study was undertaken of all adolescents 14-15 years old at the time of the initial survey and of selected 16-19 year olds who were in the high intermediate and low ranges of the blood pressure distributions Follow-up measurements included weight height and blood pressure in all subjects and sodium excretion serum cholesterol glucose triglycerides exercise and uric acid concentrations electrocardiograms and echocardiograms in the older group In 1984 the follow-up also included information on socioeconomic variables medical and family histories smoking exercise life events coronary-prone behavior and anxiety Plasma renin activity and plasma aldosterone were measured before and after treadmill exercise in those young adults with relatively high and relatively low blood pressures to determine if the renin-aldosterone axis is suppressed before the appearance of hypertension Studies were continued on physiologic psychosocial and behavioral risk factors for hypertension age-related trends in cardiovascular risk factors over time correlates of elevated blood pressure and the early cardiac consequences of high blood pressure
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL019956 | NIH | None | httpsreporternihgovquickSearchR01HL019956 |