Ignite Creation Date:
2024-05-06 @ 3:21 PM
Last Modification Date:
2024-10-26 @ 1:48 PM
Study NCT ID:
NCT04605848
Status:
TERMINATED
Last Update Posted:
2024-05-09
First Post:
2020-10-08
Brief Title:
Infrared Thermography Associated With Cutaneous Microcirculation for Detection of Brown-adipose Tissue MICROBAT
Sponsor:
University of Avignon
Organization:
University of Avignon
Study Overview
Official Title:
Infrared Thermography Associated With Cutaneous Microcirculation for Detection of Brown-adipose Tissue Proof of Concept Against PET-CT in Patients Affected by Pheochomocytoma andor Paraganglioma
Status:
TERMINATED
Status Verified Date:
2024-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
recruiting problems
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
MICROBAT
Brief Summary:
Patients affected by pheochromocytoma PHEO have brown-adipose tissue BAT hyperactivation They perform in routine settings a FDG PET-CT scan The high metabolic activity of BAT and its ability to consume both glucose and fatty acid suggest that it may have potential as a therapeutic target in the treatment of obesity However alternative non-invasive techniques to PET-CT BAT detection still need more validation Accordingly our aim will be to measure the temperature and microcirculation of the skin overlaying BAT depots in the region of FDG-uptake detected by 18F-FDG PETCT before and after a cold test in PHEO patients
Detailed Description:
Objectives and Methodology
To analyse the change in temperature and microcirculation of the skin overlaying BAT depots in the region of FDG-uptake detected by 18F-FDG PETCT before and after a cold test in PHEO patients
To check the decreased temperature and microcirculatory response after a cold test following resection of the tumor
All the patients affected by will benefit from a
clinical treatments
biological evaluations glycemia triglycerides total cholesterol HDL-C LDL-C plasma epinephrine and norepinephrine urine catecholamine
cutaneous microcirculation by means of Laser Speckle Imaging will be recorded at rest and during a cold test in the supra-clavicular region
cutaneous microcirculation by means of Laser Doppler Flowmetry will be recorded at rest and during a cold test with one probe in the supra-clavicular region and one probe in umbilical region
skin temperature by means of infrared thermography will be recorded at rest and during a cold test in the supra-clavicular region
Patients who will have surgery will be investigated before and after one year following resection of the tumor
To analyse the change in temperature and microcirculation of the skin overlaying BAT depots in the region of FDG-uptake detected by 18F-FDG PETCT before and after a cold test in PHEO patients
To check the decreased temperature and microcirculatory response after a cold test following resection of the tumor
All the patients affected by will benefit from a
clinical treatments
biological evaluations glycemia triglycerides total cholesterol HDL-C LDL-C plasma epinephrine and norepinephrine urine catecholamine
cutaneous microcirculation by means of Laser Speckle Imaging will be recorded at rest and during a cold test in the supra-clavicular region
cutaneous microcirculation by means of Laser Doppler Flowmetry will be recorded at rest and during a cold test with one probe in the supra-clavicular region and one probe in umbilical region
skin temperature by means of infrared thermography will be recorded at rest and during a cold test in the supra-clavicular region
Patients who will have surgery will be investigated before and after one year following resection of the tumor
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None