Ignite Creation Date:
2024-05-06 @ 3:21 PM
Last Modification Date:
2024-10-26 @ 1:48 PM
Study NCT ID:
NCT04606225
Status:
UNKNOWN
Last Update Posted:
2020-10-28
First Post:
2020-10-09
Brief Title:
Losartan Effects on Emotion-memory Interaction
Sponsor:
University of Electronic Science and Technology of China
Organization:
University of Electronic Science and Technology of China
Study Overview
Official Title:
The Role of the Renin-angiotensin System in Emotion-memory Interactions
Status:
UNKNOWN
Status Verified Date:
2020-10
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to investigate whether a single dose of losartan 50 mg can affect emotion-memory interaction in healthy humans and its underlying neural mechanisms
Detailed Description:
Animal models and initial findings in humans suggest a role of the renin-angiotensin system in cognitive and emotional processes Accumulating evidence demonstrates modulatory effects of the angiotensin antagonist losartan in the domains of memory and emotional processing Against this background the present study aims to investigate the behavioral and neural effects of a single dose of losartan on emotional processing and emotion-memory integration in healthy subjects In a double-blind between-subject placebo-controlled pharmaco-fMRI experiment 60 male participants will be randomized to a single dose of losartan 50 mg or placebo and encode emotional pictures during fMRI scheduled 90 minutes after drug administration Then 24 hours post fMRI participants will finish a surprise recognition memory test to estimate the emotion effects on subsequent memory
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None