Ignite Creation Date:
2024-05-06 @ 3:21 PM
Last Modification Date:
2024-10-26 @ 1:48 PM
Study NCT ID:
NCT04604847
Status:
COMPLETED
Last Update Posted:
2024-06-26
First Post:
2020-10-12
Brief Title:
Postoperative Painful Chronicization After Knee Replacement Surgery Exploratory Study of BDNFs Kinetics
Sponsor:
University Hospital Montpellier
Organization:
University Hospital Montpellier
Study Overview
Official Title:
Postoperative Painful Chronicization After Knee Replacement Surgery Exploratory Study of BDNFs Kinetics
Status:
COMPLETED
Status Verified Date:
2024-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
KNEE BDNF
Brief Summary:
Chronic pain is an extremely disabling disease It is a major public health problem due to the lack of effective therapy
Chronic postoperative pain CPOP is defined by a painful symptomatology in the operated area unrelated to previous pain present for more than 3 months and without any link to surgical complication
The prevalence of chronicization of postoperative pain is 30 after total knee arthroplasty
Identification of clinical biological and psychological profiles are crucial to prevent CPOP
A biologic factor Brain Derived Neurotrophic Factor BDNF produced by a variety of cells is a key regulator of neuroplasticity BDNF is increasingly studied in the mechanisms of cerebral sensitization and pain chronicization The role of BDNF in pain of patients remains to be explored in a prospective study The aim of this observational study is to compare the kinetics of BDNF after total knee arthroplasty in patients with and without CPOP
Patients will be included in the study at the preanesthetic consultation Serum BDNF levels will be measured preoperatively 48h postoperatively 3 and 6 months after surgery
Chronic postoperative pain CPOP is defined by a painful symptomatology in the operated area unrelated to previous pain present for more than 3 months and without any link to surgical complication
The prevalence of chronicization of postoperative pain is 30 after total knee arthroplasty
Identification of clinical biological and psychological profiles are crucial to prevent CPOP
A biologic factor Brain Derived Neurotrophic Factor BDNF produced by a variety of cells is a key regulator of neuroplasticity BDNF is increasingly studied in the mechanisms of cerebral sensitization and pain chronicization The role of BDNF in pain of patients remains to be explored in a prospective study The aim of this observational study is to compare the kinetics of BDNF after total knee arthroplasty in patients with and without CPOP
Patients will be included in the study at the preanesthetic consultation Serum BDNF levels will be measured preoperatively 48h postoperatively 3 and 6 months after surgery
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None