Ignite Creation Date:
2024-05-06 @ 3:21 PM
Last Modification Date:
2024-10-26 @ 1:48 PM
Study NCT ID:
NCT04607174
Status:
RECRUITING
Last Update Posted:
2024-03-18
First Post:
2020-10-22
Brief Title:
Voluntary Activation During Isokinetic Contractions in Subjects with Neuromotor Disorders
Sponsor:
Istituto Auxologico Italiano
Organization:
Istituto Auxologico Italiano
Study Overview
Official Title:
Measuring Voluntary Activation of the Quadriceps Femoris During Isokinetic Concentric Contractions with the Interpolated Twitch Technique ITT in Subjects with Neuromotor Disorders
Status:
RECRUITING
Status Verified Date:
2024-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
ATTILA
Brief Summary:
Activation is the amount of voluntary recruitment of a muscle during voluntary contraction Full activation implies the recruitment of all muscle fibres at their tetanic frequency In healthy subjects and even in sports performances full activation may be rarely achieved despite a subjectively maximal effort
Highly decreased activation has been observed in patients affected by various orthopaedic and neurological disorders In these subjects paresis may be caused or aggravated by primitive impairments of the central nervous system andor by stimuli arising from peripheral damaged tissues that inhibit the corticospinal or the intraspinal recruitment of motoneurones arthrogenous muscle weakness There are numerous investigations in the literature on activation measured during isometric contractions while they are substantially missing as far as isokinetic concentric contractions are concerned There are reasons to suppose that contrary to what has been demonstrated for healthy subjects in patients with various motor impairments the activation is diminished the more the higher is the joint rotation speed
The present study aims to investigate the amount of activation of the quadriceps femoris during subjectively maximal isometric contractions at 40 knee flexion 0complete extension and isokinetic concentric contractions at an angular velocity of 100s in patients with various orthopaedic and neurologic conditions
Activation will be measured on an isokinetic dynamometer through the interpolated twitch technique This consists of stimulating a representative sample of the muscle belly through an electric shock If the shock does not generate an extra force during contraction all muscle fibres belonging to the sample reached by the electric shock can be claimed to be recruited at their tetanic frequency Otherwise following the stimulus a twitch can be observed revealing submaximal voluntary recruitment of the muscle
Highly decreased activation has been observed in patients affected by various orthopaedic and neurological disorders In these subjects paresis may be caused or aggravated by primitive impairments of the central nervous system andor by stimuli arising from peripheral damaged tissues that inhibit the corticospinal or the intraspinal recruitment of motoneurones arthrogenous muscle weakness There are numerous investigations in the literature on activation measured during isometric contractions while they are substantially missing as far as isokinetic concentric contractions are concerned There are reasons to suppose that contrary to what has been demonstrated for healthy subjects in patients with various motor impairments the activation is diminished the more the higher is the joint rotation speed
The present study aims to investigate the amount of activation of the quadriceps femoris during subjectively maximal isometric contractions at 40 knee flexion 0complete extension and isokinetic concentric contractions at an angular velocity of 100s in patients with various orthopaedic and neurologic conditions
Activation will be measured on an isokinetic dynamometer through the interpolated twitch technique This consists of stimulating a representative sample of the muscle belly through an electric shock If the shock does not generate an extra force during contraction all muscle fibres belonging to the sample reached by the electric shock can be claimed to be recruited at their tetanic frequency Otherwise following the stimulus a twitch can be observed revealing submaximal voluntary recruitment of the muscle
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None