Ignite Creation Date:
2024-05-05 @ 5:13 PM
Last Modification Date:
2024-10-26 @ 9:30 AM
Study NCT ID:
NCT00419653
Status:
TERMINATED
Last Update Posted:
2008-09-16
First Post:
2007-01-08
Brief Title:
Modulation of Regional Brain Activation in Schizophrenic Patients by Pharmacological Therapy
Sponsor:
University of Jena
Organization:
University of Jena
Study Overview
Official Title:
Modulation of Regional Brain Activation in Schizophrenic Patients by Pharmacological Therapy With Amisulpride Olanzapine or Haloperidol A Study With Functional Magnetic Resonance Imaging fMRI and Diffusion Tensor Imaging DTI
Status:
TERMINATED
Status Verified Date:
2008-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Recruitment issues
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The study aims to investigate the modulation of regional brain activation in schizophrenic patients by psychopharmacological treatment with either haloperidol amisulpride or olanzapine The study will be performed with functional magnetic resonance imaging fMRI and diffusion tensor imaging DTI
Detailed Description:
The current study aims to investigate the following issues
Changes in cognitive activation patterns under therapy with the typical neuroleptic haloperidol as compared to the atypical antipsychotics amisulpride and olanzapine
Relationship of these changes in activity to psychopathological neuropsychological and pharmacotherapeutic variables eg drug plasma level as well as to certain biological markers HVA prolactin
Relationship between diffusion anisotropy as an indicator for structural connectivity and cognitive activation patterns under antipsychotic treatment
Changes in cognitive activation patterns under therapy with the typical neuroleptic haloperidol as compared to the atypical antipsychotics amisulpride and olanzapine
Relationship of these changes in activity to psychopathological neuropsychological and pharmacotherapeutic variables eg drug plasma level as well as to certain biological markers HVA prolactin
Relationship between diffusion anisotropy as an indicator for structural connectivity and cognitive activation patterns under antipsychotic treatment
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None