Ignite Creation Date:
2024-05-06 @ 3:18 PM
Last Modification Date:
2024-10-26 @ 1:47 PM
Study NCT ID:
NCT04587700
Status:
COMPLETED
Last Update Posted:
2023-08-01
First Post:
2020-10-07
Brief Title:
Analgesic Consumption in Chronic Marijuana Users Following Orthopedic Trauma Surgery
Sponsor:
University of Alberta
Organization:
University of Alberta
Study Overview
Official Title:
Analgesic Consumption in Chronic Marijuana Users Following Orthopedic Trauma Surgery
Status:
COMPLETED
Status Verified Date:
2023-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Marijuana use has increased since its legalization in Canada and many believe that it may help patients that are experiencing chronic pain The investigators want to assess if patients who have used marijuana chronically will need more medication to control their pain after they have undergone orthopedic trauma surgery ex Hip femur humerus fractures etc In this study the investigators will identify chronic marijuana users ie those using for 3 months or more who are undergoing orthopedic trauma surgery to assess how much pain medication they need post-operatively and compare this with non-users The investigators will also evaluate their pain scores pain medication use and other complications that they may have during or after their surgeries including any nauseavomiting heart or breathing problems
Detailed Description:
Since its legalization in Canada marijuana consumption has become more common while also being the most widely used illicit drug within the USA In addition to being consumed recreationally cannabis is being increasingly prescribed by medical practitioners as nearly 15 of Canadian and Australian patients experiencing chronic pain use it as one component of treatment Recent evidence has demonstrated that specific patient cohorts may benefit from cannabis including those with fibromyalgia diabetic neuropathy complex regional pain syndrome multiple sclerosis traumatic neuropathic pain and difficulty sleeping due to chronic pain amongst others Cannabis contains two main components delta-9-tetrahydrocannabinol THC which is active and cannabidiol which is inactive THC has its effects by binding to Type 1 cannabinoid receptors and inhibiting pain pathways while activation of Type 2 cannabinoid receptors have anti-inflammatory properties
As literature continues to investigate its analgesic characteristics many proponents of cannabis use believe that it can modify pain response in various settings One such setting that is of special interest for pain control is during the post-operative period Currently there is minimal data available to reflect the analgesic requirement and thus degree of pain for a patient who is a chronic marijuana user immediately following a surgical procedure A class of surgical procedures that is of particular interest to us due to its pain-evoking characteristics is orthopedic trauma surgery In fact orthopedic surgeons are one of the higher opioid prescribing specialists potentially highlighting the difficulty in achieving adequate pain control in their patient population More information is required to better tailor analgesia for these patients as it may contribute towards their overall recovery restoring mobility and patient satisfaction 67
Through this study the investigators would like to investigate the relationship between orthopedic trauma surgery and post-operative pain control in the chronic marijuana user Minimal data is available in the literature reflecting this potentially common situation Specifically the investigators are interested in the clinical implications of marijuana use on opioid consumption and verbal pain rating in this patient scenario The investigators also hope that the data can reflect possible side effects or other concerning outcomes in the peri-operative period so that clinicians may be able to provide more personalized care to these patients
As literature continues to investigate its analgesic characteristics many proponents of cannabis use believe that it can modify pain response in various settings One such setting that is of special interest for pain control is during the post-operative period Currently there is minimal data available to reflect the analgesic requirement and thus degree of pain for a patient who is a chronic marijuana user immediately following a surgical procedure A class of surgical procedures that is of particular interest to us due to its pain-evoking characteristics is orthopedic trauma surgery In fact orthopedic surgeons are one of the higher opioid prescribing specialists potentially highlighting the difficulty in achieving adequate pain control in their patient population More information is required to better tailor analgesia for these patients as it may contribute towards their overall recovery restoring mobility and patient satisfaction 67
Through this study the investigators would like to investigate the relationship between orthopedic trauma surgery and post-operative pain control in the chronic marijuana user Minimal data is available in the literature reflecting this potentially common situation Specifically the investigators are interested in the clinical implications of marijuana use on opioid consumption and verbal pain rating in this patient scenario The investigators also hope that the data can reflect possible side effects or other concerning outcomes in the peri-operative period so that clinicians may be able to provide more personalized care to these patients
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None