Viewing Study NCT04586699



Ignite Creation Date: 2024-05-06 @ 3:17 PM
Last Modification Date: 2024-10-26 @ 1:46 PM
Study NCT ID: NCT04586699
Status: RECRUITING
Last Update Posted: 2023-08-04
First Post: 2020-09-30

Brief Title: Meditation Accelerated Brain Stimulation for Depression
Sponsor: University of California San Diego
Organization: University of California San Diego

Study Overview

Official Title: Meditation Accelerated Brain Stimulation for Depression
Status: RECRUITING
Status Verified Date: 2024-08
Last Known Status: None
Delayed Posting: No
If Stopped, Why?: Not Stopped
Has Expanded Access: False
If Expanded Access, NCT#: N/A
Has Expanded Access, NCT# Status: N/A
Acronym: MediTMS
Brief Summary: Repetitive Transcranial magnetic stimulation rTMS is an FDA-approved treatment for depression that involves brief magnetic stimulation pulses on the dorsolateral prefrontal cortex DLPFC brain region The ultimate goal of this treatment is to increase excitability and long-term plasticity in DLPFC a brain region shown to be hypo-active in depression Unfortunately rTMS only has low to moderate efficacy remission rates for patients range from 15-30 in large randomized controlled trials The focus of this research is to develop a next-generation rTMS protocol that is guided by the basic principles underlying brain plasticity in order to improve the efficacy of rTMS for the treatment of depression Specifically in this study the investigators will test rTMS paired with a depression-relevant cognitive state of internal attention
Detailed Description: Repetitive Transcranial magnetic stimulation rTMS is an FDA-approved treatment for depression that involves brief magnetic stimulation pulses on the dorsolateral prefrontal cortex DLPFC brain region The ultimate goal of this treatment is to increase excitability and long-term plasticity in DLPFC a brain region shown to be hypo-active in depression Unfortunately rTMS only has low to moderate efficacy remission rates for patients range from 15-30 in large randomized controlled trials The focus of this research is to develop a next-generation rTMS protocol that is guided by the basic principles underlying brain plasticity in order to improve the efficacy of rTMS for the treatment of depression Specifically in this study the investigators will test rTMS paired with a depression-relevant cognitive state of internal attention Meditative internal focus has been shown to benefit depression Our own research shows that the neural correlates of attention-to-breath are associated with greater mindfulness Hence in this study we will pair breath training with rTMS neuro-stimulation

Study Oversight

Has Oversight DMC: None
Is a FDA Regulated Drug?: False
Is a FDA Regulated Device?: True
Is an Unapproved Device?: None
Is a PPSD?: None
Is a US Export?: True
Is an FDA AA801 Violation?: None