Ignite Creation Date:
2024-05-06 @ 3:17 PM
Last Modification Date:
2024-10-26 @ 1:47 PM
Study NCT ID:
NCT04587375
Status:
COMPLETED
Last Update Posted:
2020-10-14
First Post:
2020-06-18
Brief Title:
Diagnosis of Endocrine Dysfunctions in Covid-19
Sponsor:
University Hospital Montpellier
Organization:
University Hospital Montpellier
Study Overview
Official Title:
Diagnosis of Endocrine Dysfunctions in Covid-19 Explorations of the Plasma Renin and Aldosterone Levels in Patients With Covid-19 Infection
Status:
COMPLETED
Status Verified Date:
2020-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
Dyhor-19
Brief Summary:
As observed with SARS-CoV responsible for SARS 2003 the new coronarovirus SARS-CoV-2 uses the angiotensin converting enzyme type 2 ACE2 as cellular receptor to infect cells The renin aldosterone angiostensin system RAAS has known effects in the lungs some receptors are pro-inflammatory others are anti-inflammatory Thus the deregulation of the RAAS induced by the SARS-CoV-2 could explain the inflammatory response of Covid-19 infection and be a modulator of the severity of its course
Furthermore the SARS 2003 experience suggests that there may be others endocrine involvment particularly an failure on the hypothalamus-pituitary and adrenal axis Indeeed cases of hypocorticism and hypothyroidism of central origin were described
Altogether the endocrine system might play a role both in the pathophysiology of Covid-19 infection and in the activity and severity of the disease
In this study the investigators proposed to explore endocrine functions on biological samples in a series of patients admitted for Covid-19 in our clinic
Furthermore the SARS 2003 experience suggests that there may be others endocrine involvment particularly an failure on the hypothalamus-pituitary and adrenal axis Indeeed cases of hypocorticism and hypothyroidism of central origin were described
Altogether the endocrine system might play a role both in the pathophysiology of Covid-19 infection and in the activity and severity of the disease
In this study the investigators proposed to explore endocrine functions on biological samples in a series of patients admitted for Covid-19 in our clinic
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None