Ignite Creation Date:
2024-05-06 @ 3:16 PM
Last Modification Date:
2024-10-26 @ 1:46 PM
Study NCT ID:
NCT04575493
Status:
COMPLETED
Last Update Posted:
2021-06-24
First Post:
2020-09-25
Brief Title:
Clinical Efficacy of Crano-cure inTreatment of Urinary Tract Infection
Sponsor:
Islamia University of Bahawalpur
Organization:
Islamia University of Bahawalpur
Study Overview
Official Title:
Clinical Efficacy of Crano-cure inTreatment of Urinary Tract Infection
Status:
COMPLETED
Status Verified Date:
2021-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The main objectives of the study are to determine the efficacy of test drug Crano-cure for the treatment of urinary tract infection to compare the effectiveness of Polyherbal formulation Crano-cure vs Standard allopathic Antibacterial antibiotic Ciprofloxacin 500 mg in treatment of UTI to assess the safety of trial drug
Research literatures have revealed that Tribulus terrestris Gokhro Vaccinium macrocarpon karonda Cuminum cyminum Zeera sufaid Rheum emodi Revand chini and Piper cubeba Kabab chini are important therapeutic plants Many pharmacological researches have been done on these plants For instance antioxidant antiseptic anti-microbial anti-bacterial anticancer etc In the above claims and facts the study is conducted to formulate and evaluate the polyherbal capsule and to find out the most effective combination having anti-bacterial activity
Research literatures have revealed that Tribulus terrestris Gokhro Vaccinium macrocarpon karonda Cuminum cyminum Zeera sufaid Rheum emodi Revand chini and Piper cubeba Kabab chini are important therapeutic plants Many pharmacological researches have been done on these plants For instance antioxidant antiseptic anti-microbial anti-bacterial anticancer etc In the above claims and facts the study is conducted to formulate and evaluate the polyherbal capsule and to find out the most effective combination having anti-bacterial activity
Detailed Description:
A urinary tract infection UTI is the infection of kidney that affects urinary tract It affects the urinary bladder cystitis and kidney pyelonephritis Symptoms of urinary bladder infection are painful urination frequent micturation and urinary incontinence Symptoms of infection in kidney include pyrexia and lumber pain also in addition to symptoms of a lower urinary tract infection and rarely blood in the urine In older age and in young adults symptoms may be unclear or non-specific 1
Urinary tract infections are grouped into two types complicated and uncomplicated In uncomplicated cases of urinary tract infections the function of urinary tract system does not disturb In complicated UTI the normal function of UT system disturbs 2
Uncomplicated UTI is usually caused by E coli Staphylococcus saprophyticus Klebsiella pneumonia Proteus mirabilis Enterococcus spp While complicated UTI is caused by Similar organisms which causes uncomplicated UTI Staphylococcus spp Enterococcus spp P aeruginosa
Current studies on the prevalence of urinary tract infections approximately one third population of the world has been suffering from this disease This disease causes Pyuria burning urination heamaturia pyrexia Vaginal itching Offensive smell and turbid urine urinate frequent urgency to urinate and suprapubic pain or pain in pelvis It is not life-threatening disease Different antibacterial antibiotics are available such as Co-trimaxazole amoxicillin nitrofurantoin trimethoprim combination of trimethoprim and sulfamethoxazole and quinolone antibiotics is taken as a choice for the treatment of UTI 3 The antibacterial agents antibiotic available but they are limited in number have adverse effects resistance of bacteria to these agents and relapse of the UTI In order to overcome the problem of less availability of drugs needed to treat urinary tract infection with traditional medicine derived from medicinal plants This encouraged the search for new and dynamic antibacterial agents from plant sources
Urinary tract infections are grouped into two types complicated and uncomplicated In uncomplicated cases of urinary tract infections the function of urinary tract system does not disturb In complicated UTI the normal function of UT system disturbs 2
Uncomplicated UTI is usually caused by E coli Staphylococcus saprophyticus Klebsiella pneumonia Proteus mirabilis Enterococcus spp While complicated UTI is caused by Similar organisms which causes uncomplicated UTI Staphylococcus spp Enterococcus spp P aeruginosa
Current studies on the prevalence of urinary tract infections approximately one third population of the world has been suffering from this disease This disease causes Pyuria burning urination heamaturia pyrexia Vaginal itching Offensive smell and turbid urine urinate frequent urgency to urinate and suprapubic pain or pain in pelvis It is not life-threatening disease Different antibacterial antibiotics are available such as Co-trimaxazole amoxicillin nitrofurantoin trimethoprim combination of trimethoprim and sulfamethoxazole and quinolone antibiotics is taken as a choice for the treatment of UTI 3 The antibacterial agents antibiotic available but they are limited in number have adverse effects resistance of bacteria to these agents and relapse of the UTI In order to overcome the problem of less availability of drugs needed to treat urinary tract infection with traditional medicine derived from medicinal plants This encouraged the search for new and dynamic antibacterial agents from plant sources
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None