Ignite Creation Date:
2024-05-05 @ 5:13 PM
Last Modification Date:
2024-10-26 @ 9:29 AM
Study NCT ID:
NCT00413465
Status:
UNKNOWN
Last Update Posted:
2006-12-19
First Post:
2006-12-18
Brief Title:
Study of Renal Blood Flow During Human Endotoxemia
Sponsor:
Rigshospitalet Denmark
Organization:
Rigshospitalet Denmark
Study Overview
Official Title:
Renal Plasma Flow During Experimental Human Endotoxemia
Status:
UNKNOWN
Status Verified Date:
2006-12
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of the present protocol is to study whether endotoxemia will affect the renal blood flow in type 2 diabetics and healthy volunteers
Detailed Description:
Many septic patients develop acute renal failure and the risk is higher in patients with diabetes The pathogenetic mechanisms behind the development of acute renal failure in connection with sepsis is not completely understood One among many possible explanations is a change in renal hemodynamics However it is still largely unknown what happens to the renal plasma flow during human sepsis In this study we give endotoxin injection 03 ngkg to type 2 diabetics and healthy controls as an experimental model of sepsis Renal plasma flow and glomerular filtration rate are measured by DTPA-renography 1 day before before and 125 and 65 hours after injection of endotoxin Furthermore WBC plasma-cytokinesVCAM-1ICAM-1 endothelin-1 Thromboxane B2 angiotensin 2 renin and PAI-1 are measured on an hourly basis up to 8 hours after endotoxin injection
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None