Ignite Creation Date:
2024-05-05 @ 11:19 AM
Last Modification Date:
2024-10-26 @ 9:05 AM
Study NCT ID:
NCT00005354
Status:
COMPLETED
Last Update Posted:
2014-03-27
First Post:
2000-05-25
Brief Title:
Computed Tomography CT--An Epidemiologic Study in the Young
Sponsor:
University of Iowa
Organization:
University of Iowa
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2008-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To investigate the relationship between coronary heart disease risk factors and coronary artery calcification in middle age adults from the Muscatine Study From 1992 through 1995 ultrafast computed tomography was used to measure coronary artery calcification The study has been extended through January 2001 in order to examine the role of electron beam computed tomography in detecting the presence and quantity of coronary artery calcification a marker of the atherosclerotic process
Detailed Description:
BACKGROUND
Atherosclerotic heart disease a major cause of mortality and morbidity in the United States has been shown to have its origins in childhood Deposition of calcium occurring early in the atheromatous process is often observed in postmortem studies of coronary arteries and the aorta Ultrafast computed tomography Fast-CT provides a highly sensitive non-invasive technique for detecting the presence and quantity of coronary artery calcification CAC The risk factors for coronary artery disease have been determined by measuring levels of potential factors in middle-and older-aged adults and determining which predict atherosclerotic cardiovascular disease including coronary artery disease CAD peripheral vascular disease and cerebrovascular disease Adult subjects with CAC have a greater number of coronary risk factors including higher cholesterols In the age group of 30-39 years 30 to 40 percent have radiographic evidence of coronary artery or aortic calcification In the Muscatine Study the investigators examined coronary risk factors in 2400 subjects during childhood ages 9-11 years and again in young adult life ages 20 to 30 years This population can now provide important information related to measures of childhood and young adult coronary risk factors predicting the development of the atherosclerotic process in adults in their fourth decade of life
DESIGN NARRATIVE
Beginning in 1992 the longitudinal study used the non-invasive technique of ultrafast computed tomography to examine the relationship of known coronary risk factors measured in childhood and again in early adult life in order to correlate their association with coronary artery calcification Risk factors included lipids lipoproteins apolipoproteins lipoproteina apoa genotypes homocysteine and left ventricular mass Beginning in February 1996 electron beam computed tomography is used to associate risk factors with coronary artery calcification
Atherosclerotic heart disease a major cause of mortality and morbidity in the United States has been shown to have its origins in childhood Deposition of calcium occurring early in the atheromatous process is often observed in postmortem studies of coronary arteries and the aorta Ultrafast computed tomography Fast-CT provides a highly sensitive non-invasive technique for detecting the presence and quantity of coronary artery calcification CAC The risk factors for coronary artery disease have been determined by measuring levels of potential factors in middle-and older-aged adults and determining which predict atherosclerotic cardiovascular disease including coronary artery disease CAD peripheral vascular disease and cerebrovascular disease Adult subjects with CAC have a greater number of coronary risk factors including higher cholesterols In the age group of 30-39 years 30 to 40 percent have radiographic evidence of coronary artery or aortic calcification In the Muscatine Study the investigators examined coronary risk factors in 2400 subjects during childhood ages 9-11 years and again in young adult life ages 20 to 30 years This population can now provide important information related to measures of childhood and young adult coronary risk factors predicting the development of the atherosclerotic process in adults in their fourth decade of life
DESIGN NARRATIVE
Beginning in 1992 the longitudinal study used the non-invasive technique of ultrafast computed tomography to examine the relationship of known coronary risk factors measured in childhood and again in early adult life in order to correlate their association with coronary artery calcification Risk factors included lipids lipoproteins apolipoproteins lipoproteina apoa genotypes homocysteine and left ventricular mass Beginning in February 1996 electron beam computed tomography is used to associate risk factors with coronary artery calcification
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL048050 | NIH | None | httpsreporternihgovquickSearchR01HL048050 |