Ignite Creation Date:
2024-05-06 @ 3:14 PM
Last Modification Date:
2024-10-26 @ 1:45 PM
Study NCT ID:
NCT04565834
Status:
UNKNOWN
Last Update Posted:
2022-04-20
First Post:
2020-09-14
Brief Title:
Effect of Genetic Alterations in Key Genes in the Kynurenine Pathway on Suicidal Behavior
Sponsor:
Centre Hospitalier Universitaire de Nīmes
Organization:
Centre Hospitalier Universitaire de Nīmes
Study Overview
Official Title:
A Study on Genetic Alterations Polymorphism in Key Genes in the Kynurenine Pathway on Suicidal Behavior
Status:
UNKNOWN
Status Verified Date:
2022-01
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
SuiKYN
Brief Summary:
Current research has shown that an imbalance in the Kinurenine pathway plays a role in the physiopathology of neurogenerative and mental disorders with a decrease in neuroprotective metabolites and an increase in neurotoxic products So far the research has concentrated on the enzymes IDO KAT KMO 3HAO and QPRT which are the key players in this pathway Several polymorphisms affecting these enzymes have been associated with certain disorders characterized by a deregulation of the inflammation and immune response McCauley et al 2009Tardito et al 2013 Lee et al 2014 but no studies have ever tried to find a link between these enzymes and suicidal behavior The investigators hypothesize that people who have attempted to commit suicide will have pro-inflammatory genetic variations affecting the kynurenine pathway
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None