Ignite Creation Date:
2024-05-06 @ 3:11 PM
Last Modification Date:
2024-10-26 @ 1:44 PM
Study NCT ID:
NCT04544228
Status:
COMPLETED
Last Update Posted:
2021-03-03
First Post:
2020-08-28
Brief Title:
Ketamine or Neostigmine for Serratus Anterior Plane Block in Modified Radical Mastectomy
Sponsor:
Cairo University
Organization:
Cairo University
Study Overview
Official Title:
Comparison of Effectiveness of Adding Ketamine or Neostigmine to Bupivacaine for Ultrasound Guided Serratus Anterior Plane Block in Modified Radical Mastectomy Randomized Double Blinded Comparative Study
Status:
COMPLETED
Status Verified Date:
2021-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The aim of this study is to Investigate the analgesic efficacy of adding ketamine compared to neostigmine to local anesthetic in Ultrasound guided Serratus anterior plane block for patients undergoing Modified Radical Mastectomy
Detailed Description:
Breast cancer is the most common malignancy among females with incidence of 18660 patients each year in Egypt Modified Radical Mastectomy is considered the main surgical management for breast cancer accounting for 31 of all breast surgery cases
Ultrasound guided Serratus anterior plane block provides analgesia for breast and lateral thoracic wall surgeries by blocking nerves that are located in a compartment between the serratus anterior and the latissimus dorsi muscles the intercostobrachial nerve lateral cutaneous branches of the intercostal nerves T3-T9 long thoracic nerve and thoracodorsal nerve
A previous study demonstrated the analgesic efficacy of ketamine in patients undergoing modified pectoral nerve block in breast cancer surgery as evidenced by prolonged time to first rescue analgesia and reduced total opioid consumption
Neostigmine has been used as an additive to local anesthetics to prolong the analgesic effect Although there is good evidence for a spinal action of neostigmine its analgesic efficacy as an adjuvant to local anesthetic is still unclear
The aim of this study is to Investigate the analgesic efficacy of adding ketamine compared to neostigmine to local anesthetic in Ultrasound guided Serratus anterior plane block for patients undergoing Modified Radical Mastectomy
Ultrasound guided Serratus anterior plane block provides analgesia for breast and lateral thoracic wall surgeries by blocking nerves that are located in a compartment between the serratus anterior and the latissimus dorsi muscles the intercostobrachial nerve lateral cutaneous branches of the intercostal nerves T3-T9 long thoracic nerve and thoracodorsal nerve
A previous study demonstrated the analgesic efficacy of ketamine in patients undergoing modified pectoral nerve block in breast cancer surgery as evidenced by prolonged time to first rescue analgesia and reduced total opioid consumption
Neostigmine has been used as an additive to local anesthetics to prolong the analgesic effect Although there is good evidence for a spinal action of neostigmine its analgesic efficacy as an adjuvant to local anesthetic is still unclear
The aim of this study is to Investigate the analgesic efficacy of adding ketamine compared to neostigmine to local anesthetic in Ultrasound guided Serratus anterior plane block for patients undergoing Modified Radical Mastectomy
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None