Ignite Creation Date:
2024-05-05 @ 5:12 PM
Last Modification Date:
2024-10-26 @ 9:29 AM
Study NCT ID:
NCT00404859
Status:
COMPLETED
Last Update Posted:
2006-12-04
First Post:
2006-11-28
Brief Title:
FLAME Airway Inflammation Monitoring in Asthma and Cystic Fibrosis
Sponsor:
Maastricht University Medical Center
Organization:
Maastricht University Medical Center
Study Overview
Official Title:
Monitoring Chronic Airway Inflammation in Children With Asthma and Cystic Fibrosis
Status:
COMPLETED
Status Verified Date:
2005-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Background By means of measurements of series of non-invasive inflammatory markers in exhaled breath condensate a reflection of inflammatory processes and oxidative stress can be obtained Thereby these techniques could be important in monitoring asthma and CF lung disease in children Fractional exhaled nitric oxide FeNO and inflammatory markers in exhaled breath condensate EBC reflect ongoing inflammation and oxidative stress in the airways These markers have a promising capacity for monitoring diagnoses of CF and asthma lung disease
Aim To study the course of inflammatory markers in time in children with asthma and CF in stable periods and during pulmonary exacerbations In addition we study the ability of inflammatory markers to predict safe tapering of medical treatment in both populations
1 To study the course of inflammatory markers in EBC during an exacerbation
2 To study which IM are already elevated before a clinical exacerbation is evident and can predict exacerbations in time
3 To study which inflammatory markers can predict safe discontinuation of antibiotics in children with CF or tapering of inhaled corticosteroids in children with asthma
4 To study the relationship between inflammatory markers in EBC the severity and control of CF and asthma the symptoms and lung function within patients will be analysed
Methods Children with CF n30 and children with asthma n40 were recruited included from our outpatient clinic During this longitudinal study patients visit the outpatient clinic were followed-up for 12 months every two months during one year patients visited our outpatient clinic In addition to these standard visits During exacerbations patients four extra visits were planned during an exacerbation were asked to visit the University Hospital Maastricht four times These additional visits were planned with a maximum of two times during the study By means of a home monitor children were asked to assess measurements of Besides measurements in the University Hospital children measured forced expiratory volume in one second FEV1 at home using a home monitor to record medication use and to record presence and severity of pulmonary symptoms Outcome parameters were 1 FeNO assessment in exhaled air 2 inflammatory markers in EBC 3 lung function parameters 4 specific questionnaires to assess asthma and CF control and severity 5 data originating from the home monitor
Aim To study the course of inflammatory markers in time in children with asthma and CF in stable periods and during pulmonary exacerbations In addition we study the ability of inflammatory markers to predict safe tapering of medical treatment in both populations
1 To study the course of inflammatory markers in EBC during an exacerbation
2 To study which IM are already elevated before a clinical exacerbation is evident and can predict exacerbations in time
3 To study which inflammatory markers can predict safe discontinuation of antibiotics in children with CF or tapering of inhaled corticosteroids in children with asthma
4 To study the relationship between inflammatory markers in EBC the severity and control of CF and asthma the symptoms and lung function within patients will be analysed
Methods Children with CF n30 and children with asthma n40 were recruited included from our outpatient clinic During this longitudinal study patients visit the outpatient clinic were followed-up for 12 months every two months during one year patients visited our outpatient clinic In addition to these standard visits During exacerbations patients four extra visits were planned during an exacerbation were asked to visit the University Hospital Maastricht four times These additional visits were planned with a maximum of two times during the study By means of a home monitor children were asked to assess measurements of Besides measurements in the University Hospital children measured forced expiratory volume in one second FEV1 at home using a home monitor to record medication use and to record presence and severity of pulmonary symptoms Outcome parameters were 1 FeNO assessment in exhaled air 2 inflammatory markers in EBC 3 lung function parameters 4 specific questionnaires to assess asthma and CF control and severity 5 data originating from the home monitor
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None