Ignite Creation Date:
2024-05-06 @ 3:10 PM
Last Modification Date:
2024-10-26 @ 1:44 PM
Study NCT ID:
NCT04544891
Status:
COMPLETED
Last Update Posted:
2022-03-22
First Post:
2020-09-09
Brief Title:
TREM-1 Pathway Activation in COVID-19
Sponsor:
Central Hospital Nancy France
Organization:
Central Hospital Nancy France
Study Overview
Official Title:
Prognostic Significance of the TREM-1 Pathway Activation in COVID-19
Status:
COMPLETED
Status Verified Date:
2022-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
CoviTrem1
Brief Summary:
Severe Acute Respiratory Syndrome-Corona Virus-2 infection results in a mild infection in most of the patients However 15-20 require hospitalization and among them 15-20 will develop acute respiratory failure leading to their admission in Intensive Care Unit There are no accepted predictive criteria for aggravation Severe forms of Coronavirus induced disease-19 COVID-19 are the consequence of endotheliopathy and hyperinflammatory and pro-coagulant state The Triggering Receptor Expressed on Myeloid cells-1 TREM-1 is an immunoreceptor that acts as an amplifier of the inflammatory response TREM-1 is expressed on myeloid and endothelial cells Its activation leads to endothelial activation and damage hyperinflammatory and pro-coagulant state TREM-1 activation is associated with poor outcome during septic shock and myocardial infarction
We here aim at investigating the relationship between TREM-1 pathway activation and clinical degradation and outcome of COVID-19 hospitalized patients
We here aim at investigating the relationship between TREM-1 pathway activation and clinical degradation and outcome of COVID-19 hospitalized patients
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None