Ignite Creation Date:
2024-05-06 @ 3:10 PM
Last Modification Date:
2024-10-26 @ 1:44 PM
Study NCT ID:
NCT04540146
Status:
COMPLETED
Last Update Posted:
2021-07-27
First Post:
2020-09-04
Brief Title:
T Helper Cytokines in End Stage Colorectal Cancers
Sponsor:
Istanbul Training and Research Hospital
Organization:
Istanbul Training and Research Hospital
Study Overview
Official Title:
Evaluation of T Helper Cytokines in Intraabdominal Ascites in End Stage Colorectal Cancers
Status:
COMPLETED
Status Verified Date:
2021-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Colorectal cancers are the third most common type of cancer in the world Peritoneal carcinomatosis and intraabdominal acid development occur in advanced stages of colorectal cancers
It is known that the immune system plays an important role in tumor development or tumor eradication Differentiation of T cells towards Th2 and regulatory T cells is also reported to be effective in tumor progression
Among the mechanisms of escape from the immune system changes in the tumor microenvironment play an important role The role of regulatory T lymphocytes a subgroup of T cells that play a regulatory role by suppressing the function of other T lymphocytes is to reduce the chronic immune response against viruses tumors and patientss own antigens The common feature of all Tregs is that they secrete one or more anti-inflammatory molecules such as IL-10 TGFβ or IL-35 High levels of Tregs have been found in peripheral blood tumor tissue and lymph nodes in patients with malignancy
In our study it is aimed to evaluate whether there is a difference in intraabdominal ascites fluid T helper cytokine levels in patients with end-stage colorectal cancers compared to patients without malignancy
It is known that the immune system plays an important role in tumor development or tumor eradication Differentiation of T cells towards Th2 and regulatory T cells is also reported to be effective in tumor progression
Among the mechanisms of escape from the immune system changes in the tumor microenvironment play an important role The role of regulatory T lymphocytes a subgroup of T cells that play a regulatory role by suppressing the function of other T lymphocytes is to reduce the chronic immune response against viruses tumors and patientss own antigens The common feature of all Tregs is that they secrete one or more anti-inflammatory molecules such as IL-10 TGFβ or IL-35 High levels of Tregs have been found in peripheral blood tumor tissue and lymph nodes in patients with malignancy
In our study it is aimed to evaluate whether there is a difference in intraabdominal ascites fluid T helper cytokine levels in patients with end-stage colorectal cancers compared to patients without malignancy
Detailed Description:
Colorectal cancers are the third most common type of cancer in the world Peritoneal carcinomatosis and intraabdominal ascites development occur in advanced stages of colorectal cancers
It is known that the immune system plays an important role in tumor development or tumor eradication Differentiation of T cells towards Th2 and regulatory T cells is also reported to be effective in tumor progression
Among the mechanisms of escape from the immune system changes in the tumor microenvironment play an important role The role of regulatory T lymphocytes a subgroup of T cells that play a regulatory role by suppressing the function of other T lymphocytes is to reduce the chronic immune response against viruses tumors and patients own antigens The common feature of all Tregs is that they secrete one or more anti-inflammatory molecules such as IL-10 TGFβ or IL-35 High levels of Tregs have been found in peripheral blood tumor tissue and lymph nodes in patients with malignancy
The role of the immune system in colorectal cancers has been demonstrated with the effects of tumor-infiltrating lymphocytes TIL and immune control points on TILs or immune control point ligands on patient survival especially in recent studies Studies in the literature usually include immunological examinations of patient blood or tumor tissue
There are many publications in the literature evaluating immunological markers from ascites fluid samples for various reasons In these studies T and B cell subtypes were examined from ascites fluid samples taken from patients with ascites especially ovarian cancer and liver cirrhosis In the only study on gastrointestinal cancers immunophenotyping was performed in intraabdominal ascites and blood in 22 advanced gastrointestinal tumor patients and some cell subgroups were associated with worse clinical outcome In the literature there is no study on cytokine analysis from intra-abdominal ascites fluids specific to colorectal cancer
In our study it is aimed to evaluate whether there is a difference in intraabdominal ascites fluid cytokine level in patients with end-stage colorectal patients compared to patients without malignancy
It is known that the immune system plays an important role in tumor development or tumor eradication Differentiation of T cells towards Th2 and regulatory T cells is also reported to be effective in tumor progression
Among the mechanisms of escape from the immune system changes in the tumor microenvironment play an important role The role of regulatory T lymphocytes a subgroup of T cells that play a regulatory role by suppressing the function of other T lymphocytes is to reduce the chronic immune response against viruses tumors and patients own antigens The common feature of all Tregs is that they secrete one or more anti-inflammatory molecules such as IL-10 TGFβ or IL-35 High levels of Tregs have been found in peripheral blood tumor tissue and lymph nodes in patients with malignancy
The role of the immune system in colorectal cancers has been demonstrated with the effects of tumor-infiltrating lymphocytes TIL and immune control points on TILs or immune control point ligands on patient survival especially in recent studies Studies in the literature usually include immunological examinations of patient blood or tumor tissue
There are many publications in the literature evaluating immunological markers from ascites fluid samples for various reasons In these studies T and B cell subtypes were examined from ascites fluid samples taken from patients with ascites especially ovarian cancer and liver cirrhosis In the only study on gastrointestinal cancers immunophenotyping was performed in intraabdominal ascites and blood in 22 advanced gastrointestinal tumor patients and some cell subgroups were associated with worse clinical outcome In the literature there is no study on cytokine analysis from intra-abdominal ascites fluids specific to colorectal cancer
In our study it is aimed to evaluate whether there is a difference in intraabdominal ascites fluid cytokine level in patients with end-stage colorectal patients compared to patients without malignancy
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None