Ignite Creation Date:
2024-05-06 @ 3:09 PM
Last Modification Date:
2024-10-26 @ 1:44 PM
Study NCT ID:
NCT04547738
Status:
UNKNOWN
Last Update Posted:
2021-11-23
First Post:
2020-09-04
Brief Title:
Influence of Filarial Infections on Tuberculosis Disease and Tuberculosis Vaccination in Cameroon
Sponsor:
University Hospital Bonn
Organization:
University Hospital Bonn
Study Overview
Official Title:
Mansonella Perstans Effects on BCG Vaccine-induced Protection Against Childhood Tuberculosis TB as Well as TB Disease Severity and Recovery in Cameroon MAP-TB
Status:
UNKNOWN
Status Verified Date:
2021-11
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
MAP-TB
Brief Summary:
Filarial nematodes modulate the host immune response to promote regulatory and T helper type 2 immune responses which were shown to influence concomitant infections Indeed several studies showed that increased susceptibility and worsened disease course of HIV tuberculosis TB and malaria in filarial endemic regions Moreover the investigators demonstrated that M perstans infections polarize and suppress immune responses with likely consequences for concomitant infections and vaccine-induced protection In addition the investigators observed altered frequencies of natural killer and regulatory T and B cells in filarial and M tuberculosis co-infected individuals and that M perstans influences CD4 T cell function and immune responses upon purified protein derivative antigen stimulation Nevertheless the consequences of manifestation of TB disease and influence on TB vaccination remains unknown Thus the trial aim to address two main questions with high clinical relevance 1 Does filarial infection influence disease severity and recovery in tuberculosis patients 2 Does filarial infection influence Bacille Calmette-Guérin BCG-induced protection against disease progression in vaccinated children
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None