Ignite Creation Date:
2024-05-06 @ 3:08 PM
Last Modification Date:
2024-10-26 @ 1:44 PM
Study NCT ID:
NCT04537871
Status:
RECRUITING
Last Update Posted:
2024-05-02
First Post:
2020-08-27
Brief Title:
Cardiovascular Reserve Evaluation in Survivors of Transplant CREST Study
Sponsor:
City of Hope Medical Center
Organization:
City of Hope Medical Center
Study Overview
Official Title:
Cardiovascular Reserve Evaluation in Survivors of Transplantation CREST
Status:
RECRUITING
Status Verified Date:
2024-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study evaluates how well the heart lungs and muscles are working individually and how these systems are working together in transplant survivors Information collected in this study may help doctors to understand why hematopoietic stem cell transplant survivors are at higher risk for developing cardiovascular disease
Detailed Description:
PRIMARY OBJECTIVES
I Evaluate cardiovascular reserve capacity as measured by peak oxygen consumption VO2peak in hematopoietic cell transplantation HCT survivors
II Define the determinants of VO2peak impairment in HCT survivors
OUTLINE
Patients undergo echocardiogram to assess cardiac function and mechanics cardiopulmonary exercise test pulmonary function test musculoskeletal ultrasound bioelectrical impedance analysis to measure total lean body mass and percent body fat physical function tests and collection of blood samples within 45 days from the start of conditioning therapy and at 6 months 1 year and 2 years post-transplant
I Evaluate cardiovascular reserve capacity as measured by peak oxygen consumption VO2peak in hematopoietic cell transplantation HCT survivors
II Define the determinants of VO2peak impairment in HCT survivors
OUTLINE
Patients undergo echocardiogram to assess cardiac function and mechanics cardiopulmonary exercise test pulmonary function test musculoskeletal ultrasound bioelectrical impedance analysis to measure total lean body mass and percent body fat physical function tests and collection of blood samples within 45 days from the start of conditioning therapy and at 6 months 1 year and 2 years post-transplant
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| NCI-2020-06749 | REGISTRY | None | None |
| 19424 | OTHER | None | None |
| P30CA033572 | NIH | None | None |
| R01HL150069 | NIH | City of Hope Medical Center | httpsreporternihgovquickSearchR01HL150069 |