Ignite Creation Date:
2024-05-06 @ 3:07 PM
Last Modification Date:
2024-10-26 @ 1:43 PM
Study NCT ID:
NCT04530214
Status:
RECRUITING
Last Update Posted:
2023-04-28
First Post:
2020-08-25
Brief Title:
Predictive Elements of Trauma and Its After-effects Importance of the Quality of Neurobiological Response to Stress
Sponsor:
Direction Centrale du Service de Santé des Armées
Organization:
Direction Centrale du Service de Santé des Armées
Study Overview
Official Title:
Predictive Elements of Trauma and Its After-effects Importance of the Quality of Neurobiological Response to Stress
Status:
RECRUITING
Status Verified Date:
2023-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
LIFT-UP
Brief Summary:
The neurobiological response to stress is an adaptive response allowing us to cope with the multiple aggressions of daily life This response orchestrates the bodys systemic reaction The intensity of response to stress can modify the bodys functioning which implies a variety of fields where biomarkers may be isolated immunity psychology neurophysiology integrative physiology When stress is too intense or prolonged response to stress may become misfitted and deleterious
This study is based on the hypothesis that a severe physical or psychological trauma is associated with an intense and misfitted stress that is responsible from an undue immuno-inflammatory activation through sympathetic activation The result is a subinvasive state of systemic and tissue inflammation low-noise inflammation responsible for the mid-term deleterious consequences of the traumatic event
The objective of this study is to understand how the dysregulation of intense stress simultaneously generates an initial pathological state and an alteration of mid-term evolution which is considered as a poor prognosis andor as responsible for after-effects
The investigators wish to identify relevant biomarkers of the mechanisms activated during intense stress and influencing the immuno-inflammatory and epigenetic spheres with deleterious consequences on physiological and psychological functions
This study is based on the hypothesis that a severe physical or psychological trauma is associated with an intense and misfitted stress that is responsible from an undue immuno-inflammatory activation through sympathetic activation The result is a subinvasive state of systemic and tissue inflammation low-noise inflammation responsible for the mid-term deleterious consequences of the traumatic event
The objective of this study is to understand how the dysregulation of intense stress simultaneously generates an initial pathological state and an alteration of mid-term evolution which is considered as a poor prognosis andor as responsible for after-effects
The investigators wish to identify relevant biomarkers of the mechanisms activated during intense stress and influencing the immuno-inflammatory and epigenetic spheres with deleterious consequences on physiological and psychological functions
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 2019-A01811-56 | OTHER | IDRCB | None |