Ignite Creation Date:
2024-05-06 @ 3:07 PM
Last Modification Date:
2024-10-26 @ 1:43 PM
Study NCT ID:
NCT04524156
Status:
UNKNOWN
Last Update Posted:
2020-08-24
First Post:
2020-04-30
Brief Title:
COVID-19 Transcutaneous pO2 and pCO2 as Predictive Factors for Acute Respiratory Destress Syndrome in Patients Affected With SARS-Cov-2
Sponsor:
Erasme University Hospital
Organization:
Erasme University Hospital
Study Overview
Official Title:
COVID-19 Transcutaneous pO2 and pCO2 as Predictive Factors for Acute Respiratory Destress Syndrome in Patients Affected With SARS-Cov-2
Status:
UNKNOWN
Status Verified Date:
2020-08
Last Known Status:
NOT_YET_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
COVID-pO2-RAAS
Brief Summary:
The first case of a person infected with SARS-Cov-2 virus can be tracked back on November the 17th 2019 in China On March 11 2020 the World Health Organization WHO declared COVID-19 outbreak a pandemic On April 13 COVID-19 is affecting 210 countries and territories worldwide about 2 million positive cases have been officially declared along with 115000 deaths The real number of infected and deaths is scarily higher considering that up to 65 people are asymptomatic and thus not tested
The percentage of patients with COVID-19 needed for intensive care unit ICU varied from 5 to 32 in Wuhan China It was up to 9 in Lombardy Italy According to available data from Lombardy 99 of patients admitted to the ICU needed respiratory support 88 invasive ventilation 11 non invasive ventilation
The aim of the present investigation is to test the hypothesis whether transcutaneous partial O2 and CO2 pressures may be reliable predictive factors for acute respiratory distress syndrome ARDS development in hospitalized clinically stable COVID-19 positive patients and to clarify the role of the Angiotensin Converting Enzyme 2 ACE2 and its final product angiotensin 2 Ang II in the pathogenesis of this systemic disease
We also aim to test the hypothesis that plasma concentration of Clara Cell protein CC16 and surfactant protein D SPD which are a biomarkers of acute lung injury are severely decreased in COVID-19 positive patients and the plasma concentration is related to the severity of lung injury
The percentage of patients with COVID-19 needed for intensive care unit ICU varied from 5 to 32 in Wuhan China It was up to 9 in Lombardy Italy According to available data from Lombardy 99 of patients admitted to the ICU needed respiratory support 88 invasive ventilation 11 non invasive ventilation
The aim of the present investigation is to test the hypothesis whether transcutaneous partial O2 and CO2 pressures may be reliable predictive factors for acute respiratory distress syndrome ARDS development in hospitalized clinically stable COVID-19 positive patients and to clarify the role of the Angiotensin Converting Enzyme 2 ACE2 and its final product angiotensin 2 Ang II in the pathogenesis of this systemic disease
We also aim to test the hypothesis that plasma concentration of Clara Cell protein CC16 and surfactant protein D SPD which are a biomarkers of acute lung injury are severely decreased in COVID-19 positive patients and the plasma concentration is related to the severity of lung injury
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None