Ignite Creation Date:
2024-05-05 @ 5:12 PM
Last Modification Date:
2024-10-26 @ 9:29 AM
Study NCT ID:
NCT00407784
Status:
UNKNOWN
Last Update Posted:
2007-03-07
First Post:
2006-12-04
Brief Title:
Diagnostic Properties of Aldosterone-Renin Ratio in Primary Aldosteronism Among Hypertensives
Sponsor:
Erasmus Medical Center
Organization:
Erasmus Medical Center
Study Overview
Official Title:
Aldosterone-Renin Ratio to Diagnose Primary Aldosteronism in a Population of Patients With Therapy-Resistant Hypertension Test Characteristics Diagnostic Value and Predictive Value for Antihypertensive Treatment The Dutch ARRAT Study
Status:
UNKNOWN
Status Verified Date:
2007-03
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study aims to evaluate the diagnostic value of the Aldosterone-Renin Ratio ARRas a screening test for primary aldosteronism among hypertensives The test characteristics will be studied Furthermore the effect of eplerenone a selective aldosterone-receptor antagonist will be studied
Detailed Description:
Although primary aldosteronism PA was formerly seen as a rare cause of hypertension this condition is now thought to be the commonest cause of secondary hypertension with the prevalence ranging up to 10-15 of all hypertensives Identification of patients with PA allows for specific treatment for instance unilateral adrenalectomy in case of an aldosterone-producing adenoma or the administration of an aldosterone-receptor antagonist in case of bilateral adrenal hyperplasia
Since the introduction of the aldosterone-renin ratio ARR as a screening tool for PA in 1981 there has been considerable debate about the diagnostic value The values for aldosterone and renin are highly dependent on many factors including posture time of day and medication Also the cut-off values for the identification of PA remain controversial
This study aims to evaluate the test characteristics of the ARR in a population of patients with therapy-resistant hypertension the dependence of the ARR on medication type and the predictive value on the response on eplerenone a selective aldosterone-receptor antagonist
Since the introduction of the aldosterone-renin ratio ARR as a screening tool for PA in 1981 there has been considerable debate about the diagnostic value The values for aldosterone and renin are highly dependent on many factors including posture time of day and medication Also the cut-off values for the identification of PA remain controversial
This study aims to evaluate the test characteristics of the ARR in a population of patients with therapy-resistant hypertension the dependence of the ARR on medication type and the predictive value on the response on eplerenone a selective aldosterone-receptor antagonist
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| EudraCT nr 2006-006618-13 | None | None | None |
| C052151 | None | None | None |