Ignite Creation Date:
2024-05-06 @ 3:05 PM
Last Modification Date:
2024-10-26 @ 1:42 PM
Study NCT ID:
NCT04511403
Status:
UNKNOWN
Last Update Posted:
2020-08-13
First Post:
2020-08-08
Brief Title:
Prevalence of Oral Mucosal Alterations In a Sample of Egyptian Patients With Cardiovascular Diseases A Hospital- Based Cross-Sectional Study
Sponsor:
Cairo University
Organization:
Cairo University
Study Overview
Official Title:
Prevalence of Oral Mucosal Alterations In a Sample of Egyptian Patients With Cardiovascular Diseases A Hospital- Based Cross-Sectional Study
Status:
UNKNOWN
Status Verified Date:
2020-08
Last Known Status:
NOT_YET_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
to assess the oral mucosal alterations and their prevalence secondary to use cardiovascular drugs in a sample of Egyptian population with cardiovascular diseases
Detailed Description:
Cardiovascular diseases CVD still a major cause of health loss for all regions of the world Sociodemographic change over the past 25 years has been associated with the dramatic decrease in CVD in regions with very high sociodemographic index SDI but only a gradual decrease or no change in most regions Roth et al 2017
Statistics from the World Health Organization indicates that cardiovascular diseases are the leading cause of death in Egypt accounting for 46 of total deaths Royal Philips2018
The mouth serves as a mirror of health or disease as a sentinel or early warning system as an accessible model for the study of other tissues and organs and as a potential source of pathology affecting other systems and organs Dr Shantala Arunkumar 2013
The oral cavity is considered as a window to the body because oral manifestations accompany many systemic diseases In many instances oral involvement first appears than other symptoms or lesions at other locations These oral manifestations must be properly recognized if the patient is to receive appropriate diagnosis and referral for treatment Mehrotra et al 2010b
People with cardiovascular disease and who are at high cardiovascular risk due to the presence of one or more risk factors such as hypertension diabetes hyperlipidaemia or already established disease need early detection and management using counselling and medicines as appropriateWorld Health Organization 2013
A great many cardiovascular drugs have adverse reactions in the mouth in the form of xerostomia lichenoid reactions burning mouth sensation loss of taste sensation gingival hyperplasia and bleedingArunkumar 2013
Cardiovascular disease is the main cause of early death among people with diabetes People with diabetes also suffer from hypertension dyslipidaemia and obesity which contribute to increased incidence of cardiovascular disease Malik and Dwivedi 2015
CVDs are a leading cause of death worldwide including the Middle East This is caused in part by the dysregulation of adipose tissue cause increasing in production of pro-inflammatory adipokines and reduction in cardio-protective adipokines such as adiponectin Abu-Farha Behbehani and Elkum 2014
Low- and middle-income countries are disproportionally affected over 80 of CVD deaths take place in low- and middle-income countries and occur almost equally in men and women By 2030 almost 236 million people will die from CVDs mainly from heart disease and stroke WHO 2015
Medications used for management of hypertension cause oral alternation like Diuretics cause oral dryness adrenergic inhibitors cause oral dryness and ulcerations calcium antagonists cause overgrowth of gingiva while ACE inhibitors affect test sensation and lichenoid reactions of the oral mucosa Mehrotra et al 2010
Statistics from the World Health Organization indicates that cardiovascular diseases are the leading cause of death in Egypt accounting for 46 of total deaths Royal Philips2018
The mouth serves as a mirror of health or disease as a sentinel or early warning system as an accessible model for the study of other tissues and organs and as a potential source of pathology affecting other systems and organs Dr Shantala Arunkumar 2013
The oral cavity is considered as a window to the body because oral manifestations accompany many systemic diseases In many instances oral involvement first appears than other symptoms or lesions at other locations These oral manifestations must be properly recognized if the patient is to receive appropriate diagnosis and referral for treatment Mehrotra et al 2010b
People with cardiovascular disease and who are at high cardiovascular risk due to the presence of one or more risk factors such as hypertension diabetes hyperlipidaemia or already established disease need early detection and management using counselling and medicines as appropriateWorld Health Organization 2013
A great many cardiovascular drugs have adverse reactions in the mouth in the form of xerostomia lichenoid reactions burning mouth sensation loss of taste sensation gingival hyperplasia and bleedingArunkumar 2013
Cardiovascular disease is the main cause of early death among people with diabetes People with diabetes also suffer from hypertension dyslipidaemia and obesity which contribute to increased incidence of cardiovascular disease Malik and Dwivedi 2015
CVDs are a leading cause of death worldwide including the Middle East This is caused in part by the dysregulation of adipose tissue cause increasing in production of pro-inflammatory adipokines and reduction in cardio-protective adipokines such as adiponectin Abu-Farha Behbehani and Elkum 2014
Low- and middle-income countries are disproportionally affected over 80 of CVD deaths take place in low- and middle-income countries and occur almost equally in men and women By 2030 almost 236 million people will die from CVDs mainly from heart disease and stroke WHO 2015
Medications used for management of hypertension cause oral alternation like Diuretics cause oral dryness adrenergic inhibitors cause oral dryness and ulcerations calcium antagonists cause overgrowth of gingiva while ACE inhibitors affect test sensation and lichenoid reactions of the oral mucosa Mehrotra et al 2010
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None