Ignite Creation Date:
2024-05-06 @ 3:05 PM
Last Modification Date:
2024-10-26 @ 1:42 PM
Study NCT ID:
NCT04512209
Status:
RECRUITING
Last Update Posted:
2024-02-28
First Post:
2020-07-31
Brief Title:
Characterization of Biophysical Stromal Properties in Human Cancer Towards Personalized Computational Oncology
Sponsor:
University Hospital Ghent
Organization:
University Hospital Ghent
Study Overview
Official Title:
Characterization of Biophysical Stromal Properties in Human Cancer Towards Personalized Computational Oncology
Status:
RECRUITING
Status Verified Date:
2024-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
DCE-MRI
Brief Summary:
Drug delivery in solid tumors whether administered systemically or locoregionally is hindered by an elevated interstitial fluid pressure IFP Stromal targeting therapies are in active development aiming to enhance drug transport after systemic or locoregional delivery To date no clinical methods are available to quantify tumor biophysical properties including IFP The investigators aim to use a combination of dynamic contrast enhanced MRI and computational fluid modeling CFD to measure stromal IFP in patients with pancreatic cancer and in patients with ovarian or colonic peritoneal carcinomatosis PC Computational data will be correlated with therapy response platinum drug penetration and invasively measured biophysical parameters after intravenous pancreas or intraperitoneal ovariancolonic PC administration of a platinum compound This would be the first in depth clinical study addressing this important topic and could pave the way to developing personalized computational based treatment approaches aimed at targeting the biophysical environment of the tumor stroma in order to enhance cancer drug delivery
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None