Ignite Creation Date:
2024-05-06 @ 3:05 PM
Last Modification Date:
2024-10-26 @ 1:42 PM
Study NCT ID:
NCT04518722
Status:
RECRUITING
Last Update Posted:
2024-04-09
First Post:
2020-08-14
Brief Title:
CT-Based Changes in Bone and Marrow Among Patients on Oral Steroids
Sponsor:
University of Iowa
Organization:
University of Iowa
Study Overview
Official Title:
CT-Based Changes in Bone and Marrow Among Patients on Oral Steroids
Status:
RECRUITING
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The goal of this study is to assess the feasibility of emerging CT-based tools to measure changes in central and peripheral bone density micro-structure and marrow adipose tissue MAT among patients treated with oral steroids
Detailed Description:
This study aims to prove that emerging CT-based tools are suitable to measure changes in central and peripheral bone density geometry micro-structure and marrow adipose tissue MAT among patients treated with oral steroids To do this investigators will recruit 10 non-smokers defined as 10 pack-year smoking history age 25-45 years with a diagnosis of severe persistent asthma who either chronically use oral steroids or do not use any oral steroids Participants will undergo dual-energy X-ray absorptiometry DXA dual-energy mid-tibia CT high-resolution single-energy ankle CT and low-radiation hip CT scans at baseline and 6-month follow-up visits The images obtained will be used to analyze cross-sectional differences in central and peripheral bone density geometry micro-structure and MAT between patients using oral steroids versus those who do not use any oral steroids Differences in imaging at baseline and six-month follow visits will be used to analyze longitudinal bone changes among patients with oral steroid treatment
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
False
Is an FDA AA801 Violation?:
None