Ignite Creation Date:
2024-05-05 @ 11:19 AM
Last Modification Date:
2024-10-26 @ 9:05 AM
Study NCT ID:
NCT00005342
Status:
COMPLETED
Last Update Posted:
2016-02-29
First Post:
2000-05-25
Brief Title:
Weight Set-Point and HDL Concentration in Runners
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Heart Lung and Blood Institute NHLBI
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2000-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To investigate the differences in diet fat cell morphology and lipoprotein metabolism in previously- overweight and naturally lean men and women who ran and who lived sedentary lifestyles in order to better understand the relationship between lipoprotein metabolism and weight set-point
Detailed Description:
BACKGROUND
The elevated high-density lipoprotein HDL cholesterol concentrations of long distance runners has been ascribed almost exclusively to increased muscle lipoprotein lipase Based on data collected in cross-sectional and longitudinal studies the investigators proposed an alternative theory long-distance runners had the HDL-cholesterol metabolism of men who were below their sedentary weight rather than the HDL-cholesterol metabolism of lean sedentary men who were at their usual sedentary weight In other analyses they found that the most significant determinant of male runners plasma HDL-cholesterol concentrations was the difference between the runners greatest weight and their current weight HDL- cholesterol levels were highest in runners who had lost the most weight ie highest in those who were presumed to be the furthest below their weight set-point
The study was a result of a Program Announcement PA released in October 1994 on Physical Activity and Cardiopulmonary Health The PA was jointly sponsored by the NHLBI the National Institute of Diabetes and Digestive and Kidney Diseases and the National Institute of Nursing Research
DESIGN NARRATIVE
In this cross-sectional study runners and sedentary men and women were measured for lipoprotein cholesterol triglycerides polyacrylamide gel electrophoresis of HDL and low-density lipoprotein subclasses apolipoproteins A-I and B intravenous fat clearance rate post-heparin lipoprotein lipase and hepatic lipase adipose tissue lipoprotein lipase cholesteryl ester transfer activity diet percent body fat and regional adiposity It was hoped that the survey would confirm or reject the weight set-point hypothesis provide a possible explanation of the lipoprotein differences between male and female runners and elucidate the mechanism for the lipoprotein changes that occur during exercise-induced weight loss
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
The elevated high-density lipoprotein HDL cholesterol concentrations of long distance runners has been ascribed almost exclusively to increased muscle lipoprotein lipase Based on data collected in cross-sectional and longitudinal studies the investigators proposed an alternative theory long-distance runners had the HDL-cholesterol metabolism of men who were below their sedentary weight rather than the HDL-cholesterol metabolism of lean sedentary men who were at their usual sedentary weight In other analyses they found that the most significant determinant of male runners plasma HDL-cholesterol concentrations was the difference between the runners greatest weight and their current weight HDL- cholesterol levels were highest in runners who had lost the most weight ie highest in those who were presumed to be the furthest below their weight set-point
The study was a result of a Program Announcement PA released in October 1994 on Physical Activity and Cardiopulmonary Health The PA was jointly sponsored by the NHLBI the National Institute of Diabetes and Digestive and Kidney Diseases and the National Institute of Nursing Research
DESIGN NARRATIVE
In this cross-sectional study runners and sedentary men and women were measured for lipoprotein cholesterol triglycerides polyacrylamide gel electrophoresis of HDL and low-density lipoprotein subclasses apolipoproteins A-I and B intravenous fat clearance rate post-heparin lipoprotein lipase and hepatic lipase adipose tissue lipoprotein lipase cholesteryl ester transfer activity diet percent body fat and regional adiposity It was hoped that the survey would confirm or reject the weight set-point hypothesis provide a possible explanation of the lipoprotein differences between male and female runners and elucidate the mechanism for the lipoprotein changes that occur during exercise-induced weight loss
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL045652 | NIH | None | httpsreporternihgovquickSearchR01HL045652 |