Ignite Creation Date:
2024-05-06 @ 3:03 PM
Last Modification Date:
2024-10-26 @ 1:42 PM
Study NCT ID:
NCT04518553
Status:
UNKNOWN
Last Update Posted:
2021-03-17
First Post:
2020-08-11
Brief Title:
Plasma Purification and Chronic Hepatitis B
Sponsor:
Shanghai Pudong Hospital
Organization:
Shanghai Pudong Hospital
Study Overview
Official Title:
Shanghai Pudong Hospital
Status:
UNKNOWN
Status Verified Date:
2020-08
Last Known Status:
NOT_YET_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To compare the efficacy of nucleoside analogues HA alone and plasma purification HA in reducing HBV viral load
Detailed Description:
Chronic hepatitis B CHB is a major disease harmful to human health and an important cause of liver cirrhosis and liver cancer Hepatitis B virus HBV cccDNA exists for a long time in the liver of infected persons and serves as a template for HBV replication which makes it difficult to eradicate HEPATITIS B virus infection Antiviral drugs are commonly used clinically including interferon and nucleoside analogues but there are problems of recurrence and drug resistance These drugs are not directly targeted at cccDNA and are therefore inefficient at reducing cccDNA How to quickly and efficiently reduce the viral load of HBV-DNA inhibit THE TRANSCRIPTION of HBV-CCCDNA RNA and promote the negative conversion of HBeAg is an urgent problem to be solved at present so it is particularly important to find other more effective drugs or methods Plasma purification is a new treatment method in which the pathogenic factors hepatitis B virus etc are trapped in the hollow fibers by special membrane materials and removed Therefore this study adopts the randomized control method to explore the effect of plasma purification on HBV clearance aiming to explore the effectiveness and safety of plasma purification in reducing HBV DNA viral load and inhibiting HBV cccDNA RNA transcription so as to provide new treatment ideas and methods for future treatment of hepatitis B virus infection which is beneficial to the society and individuals
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None