Ignite Creation Date:
2024-05-05 @ 11:19 AM
Last Modification Date:
2024-10-26 @ 9:02 AM
Study NCT ID:
NCT00001301
Status:
COMPLETED
Last Update Posted:
2008-03-04
First Post:
1999-11-03
Brief Title:
Chronic and Late Effects of Non-Hodgkins Lymphoma and Its Treatment in Long Term Survivors
Sponsor:
National Cancer Institute NCI
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Chronic and Late Effects of Non-Hodgkins Lymphoma and Its Treatment in Long Term Survivors
Status:
COMPLETED
Status Verified Date:
1999-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Non-Hodgkins lymphoma has been studied in the Pediatric Branch for at least 20 years during which time a number of different treatment protocols have been used Approximately 110 patients have apparently been cured of their lymphoma The present protocol has no therapeutic component but is designed to document the late effects that may have been encountered by our patients either as a consequence of the disease or its treatment In essence patients who consent to participate will be asked a series of questions pertaining to the quality of their life and possible medical problems that they may be encountering In addition they will receive a complete physical examination and undergo non-invasive investigations designed to identify the presence of unsuspected late effects Investigators in the Eye Clinic Dental Clinic Audiology Cardiology and Endocrinology departments will participate in the protocol As a part of the study blood samples will be obtained to investigate the possibility that predisposing genetic factors may be identifiable in the patients normal cells eg p53 mutations evidence of DNA instability If such abnormalities are detected blood samples from family members will also be examined to determine whether the defect was inherited
Detailed Description:
Non-Hodgkins lymphoma has been studied in the Pediatric Branch for at least 20 years during which time a number of different treatment protocols have been used Approximately 110 patients have apparently been cured of their lymphoma The present protocol has no therapeutic component but is designed to document the late effects that may have been encountered by our patients either as a consequence of the disease or its treatment In essence patients who consent to participate will be asked a series of questions pertaining to the quality of their life and possible medical problems that they may be encountering In addition they will receive a complete physical examination and undergo non-invasive investigations designed to identify the presence of unsuspected late effects Investigators in the Eye Clinic Dental Clinic Audiology Cardiology and Endocrinology departments will participate in the protocol As a part of the study blood samples will be obtained to investigate the possibility that predisposing genetic factors may be identifiable in the patients normal cells eg p53 mutations evidence of DNA instability If such abnormalities are detected blood samples from family members will also be examined to determine whether the defect was inherited
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 92-C-0242 | None | None | None |