Ignite Creation Date:
2024-05-06 @ 3:03 PM
Last Modification Date:
2024-10-26 @ 1:42 PM
Study NCT ID:
NCT04503252
Status:
COMPLETED
Last Update Posted:
2022-03-29
First Post:
2020-07-29
Brief Title:
Probability of Target Attainment With Standard Intermittent Bolus Administration of Cefazolin in Patients With Complicated Infections Caused by Staphylococcus Aureus
Sponsor:
University Hospital Basel Switzerland
Organization:
University Hospital Basel Switzerland
Study Overview
Official Title:
Probability of Target Attainment With Standard Intermittent Bolus Administration of Cefazolin in Patients With Complicated Infections Caused by Staphylococcus Aureus A Prospective Single-center Cohort Study
Status:
COMPLETED
Status Verified Date:
2022-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
TARGET II
Brief Summary:
Given the paucity of pharmacological data on cefazolin treatment of Methicillin-susceptible S aureus MSSA complicated S aureus infection CSAI the primary purpose of this study is to investigate the probability of pharmacological target attainment in the blood and infected tissue with standard intermittent bolus administration of cefazolin in patients with CSAI caused by MSSA by determining plasma concentrations of cefazolin and exact Minimum inhibitory concentration MICs of the causative MSSA strains in patients with various disease severities eg critically ill vs noncritically ill patients
Sub-study quantitative measurement of Torque Teno virus TTV The primary purpose of this sub-study is to describe the viral kinetics of TTV in CSAI patients and to explore the association of TTV viremia with clinical outcomes and molecular markers of activation of the immune system
Sub-study investigating antibiotic concentrations in sweat as a non-invasive therapeutic drug monitoring
Sub-study quantitative measurement of Torque Teno virus TTV The primary purpose of this sub-study is to describe the viral kinetics of TTV in CSAI patients and to explore the association of TTV viremia with clinical outcomes and molecular markers of activation of the immune system
Sub-study investigating antibiotic concentrations in sweat as a non-invasive therapeutic drug monitoring
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None