Ignite Creation Date:
2024-05-06 @ 3:02 PM
Last Modification Date:
2024-10-26 @ 1:41 PM
Study NCT ID:
NCT04500769
Status:
COMPLETED
Last Update Posted:
2024-01-17
First Post:
2020-07-29
Brief Title:
Training Induced Muscle Exosome Release
Sponsor:
John McCarthy
Organization:
University of Kentucky
Study Overview
Official Title:
Exercise-induced Skeletal Muscle Exosomes Promote Adipocyte Lipolysis
Status:
COMPLETED
Status Verified Date:
2023-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
TIMER
Brief Summary:
The primary objective of this study is to quantify miR-1 release from muscle in extra-cellular vesicles following an acute resistance exercise bout and potential delivery to subcutaneous adipose tissue in young healthy and obese adults
Detailed Description:
Numerous studies in humans and animals have shown that aerobic exercise is beneficial to adipose tissue function and whole-body metabolism Both acute and chronic aerobic exercise enhance adipocyte catecholamine sensitivity in humans and animals Although relatively few studies have investigated whether adipose adrenergic signaling is affected by resistance exercise RE it is known that a single bout of RE can increase circulating NEFA and resting energy expenditure and decrease respiratory quotient for up to 24 hours indicative of increased adipocyte lipolysis and muscle fatty acid oxidation Furthermore the lipolytic response to RE is impaired in obese men Using synergist ablation a model of RE in mice the investigators show that adipose transcriptional responses are exosome-dependent and that serum exosomes enhance adipocyte catecholamine sensitivity and lipolysis for at least 24 hours To the investigators knowledge this is the first demonstration of a potential mechanism whereby RE imparts metabolic adaptations in adipose Since adipose metabolic function is crucial for determining whole-body metabolic outcomes the ability of RE-induced exosomes to improve adipose metabolism has significant clinical implications
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 3R01DK119619-02S1 | NIH | None | httpsreporternihgovquickSearch3R01DK119619-02S1 |