Ignite Creation Date:
2024-05-06 @ 3:02 PM
Last Modification Date:
2024-10-26 @ 1:42 PM
Study NCT ID:
NCT04503057
Status:
RECRUITING
Last Update Posted:
2022-04-12
First Post:
2020-08-03
Brief Title:
Exhaled Breath Particles as a Clinical Indicator for Lung Injury and Acute Respiratory Distress Syndrome ARDS
Sponsor:
Lund University Hospital
Organization:
Lund University Hospital
Study Overview
Official Title:
Exhaled Breath Particles as a Clinical Indicator for Acute Lung Injury ALI and Acute Respiratory Distress Syndrome ARDS in Coronavirus Covid-19 Positive and Negative Patients
Status:
RECRUITING
Status Verified Date:
2022-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Acute Respiratory Distress Syndrome ARDS reflects the hallmark of the critical course of coronavirus COVID19 The investigators have recently shown that Exhaled Breath Particles EBP measured as particle flow rate PFR from the airways could be used as a noninvasive real-time early detection method for primary graft dysfunction which bears a pathophysiological resemblance to ARDS in lung transplant patients The investigators have also previously demonstrated the utility of PFR in early detection and monitoring of ARDS in a large animal model PFR has been shown to be elevated prior to the cytokine storm which classically occurs in ARDS Early detection of ALI and ARDS is intimately linked to a patients chance of survival as early treatment consisting of the preparation for intensive care prone positioning and protective mechanical ventilation can be implemented early in the process In the present study the investigators aim to use real-time PFR as an early detector for COVID19-induced ARDS The investigators will also collect EBPs onto a membrane for subsequent molecular analysis Previous studies have shown that most of those proteins found in bronchoalveolar lavage BAL can also be detected in EBPs deposited on membranes The investigators therefore also aim to be able to diagnose COVID19 by analyzing EBPs using Polymerase Chain Reaction PCR with the same specificity as PCR from BAL with the added benefit of being able to identify protein biomarkers for early detection of ARDS
Detailed Description:
EBP will be measured on 100 patients who are coronavirus COVID-19 positive as indicated by PCR tests Measurement will be done on daily basis from the time the patient is admitted to the hospital as an inpatient until either discharge or transition to ICU care The initiation of mechanical ventilation in ICU patients will facilitate the tracking of EBP patterns over the course of disease in each patient EBP measurements will also be done on 100 patients without COVID19 infection who have normal lung function as a control cohort
The study will involve measurements on patients who have been placed on mechanical ventilation in the ICU The purpose of utilizing PFR will be to reduce the need for invasive diagnostic tests such as bronchoscopy and for hospital transportation associated with tests such as CT scans This will ultimately serve to not only decrease the risk of infecting other patients and staff in the hospital environment but also to facilitate careful monitoring of these critical patients by measuring the extent of lung injury over time In addition to PFR EBP will be collected and measured on a daily basis to track the EBP patterns on patients in mechanical ventilation Pre-clinical studies have shown that EBP can measure the extent of lung injury over time onset of ARDS and recovery unpublished data
Measurements are also planned for patients who are on mechanical ventilation on extracorporeal membrane oxygenation ECMO support as well
The study will involve measurements on patients who have been placed on mechanical ventilation in the ICU The purpose of utilizing PFR will be to reduce the need for invasive diagnostic tests such as bronchoscopy and for hospital transportation associated with tests such as CT scans This will ultimately serve to not only decrease the risk of infecting other patients and staff in the hospital environment but also to facilitate careful monitoring of these critical patients by measuring the extent of lung injury over time In addition to PFR EBP will be collected and measured on a daily basis to track the EBP patterns on patients in mechanical ventilation Pre-clinical studies have shown that EBP can measure the extent of lung injury over time onset of ARDS and recovery unpublished data
Measurements are also planned for patients who are on mechanical ventilation on extracorporeal membrane oxygenation ECMO support as well
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None