Ignite Creation Date:
2024-05-06 @ 3:01 PM
Last Modification Date:
2024-10-26 @ 1:41 PM
Study NCT ID:
NCT04492098
Status:
COMPLETED
Last Update Posted:
2023-01-31
First Post:
2020-07-27
Brief Title:
Mucosal-Associated Invariant T Cells in Cases of Miscarriage
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
Analysis of Mucosal-Associated Invariant T MAIT Cells in Cases of Spontaneous and Recurrent Miscarriage
Status:
COMPLETED
Status Verified Date:
2023-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Miscarriage is the most frequently encountered complication of pregnancy ranging from 10 to 30 The etiology of recurrent spontaneous miscarriage RSM in 40-50 of cases cannot be identified Immunological disturbances have been suggested to play an important role
Previous studies have focused that women with miscarriage have elevated NK cell numbers and activity both in the periphery and in the endometrium Also NK cells in women with RSM displayed an imbalance of Killer cell Ig-like receptors KIRs in favor of activating KIR leading to an unbalanced activation of dNK cytotoxicity and higher risk of miscarriage
Previous studies have focused that women with miscarriage have elevated NK cell numbers and activity both in the periphery and in the endometrium Also NK cells in women with RSM displayed an imbalance of Killer cell Ig-like receptors KIRs in favor of activating KIR leading to an unbalanced activation of dNK cytotoxicity and higher risk of miscarriage
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None