Ignite Creation Date:
2024-05-05 @ 5:11 PM
Last Modification Date:
2024-10-26 @ 9:28 AM
Study NCT ID:
NCT00400192
Status:
COMPLETED
Last Update Posted:
2013-04-15
First Post:
2006-11-15
Brief Title:
Transfusion-Associated Microchimerism in Individuals Receiving a Blood Transfusion After a Traumatic Injury
Sponsor:
Vitalant Research Institute
Organization:
Vitalant Research Institute
Study Overview
Official Title:
Prospective Study of the Kinetics and Mechanisms of Transfusion-associated Microchimerism in Injured Patients
Status:
COMPLETED
Status Verified Date:
2013-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Individuals who experience a traumatic injury often have a significant amount of blood loss and may require a blood transfusion In some individuals who receive a blood transfusion white blood cells from the donors blood may remain in the body for years a condition known as microchimerism This study will examine the reasons why microchimerism occurs in some blood transfusion recipients and not others
Detailed Description:
Approximately 20 of individuals who suffer a traumatic injury require a blood transfusion of these 10 to 15 experience a condition known as transfusion-associated microchimerism This occurs when white blood cells or leukocytes from the donors blood persist in the recipient long after the transfusion occurs The genetically distinct donor cells can remain in the individual for decades and may account for as many as 4 of the white blood cells in the recipients body This suggests that the donor cells are tolerated by the recipients immune system The purpose of this study is to examine the specific factors that predispose some blood transfusion recipients to develop microchimerism
In this study blood samples will be collected from injured individuals who arrive at the University of California at Davis Medical Center Individuals who receive a blood transfusion as well as a control group of individuals who do not receive a transfusion will be approached to enroll in the study Individuals who agree to participate will have their blood collected at Days 7 14 and 28 and Months 3 and 6 Study researchers will analyze the blood for evidence of microchimerism Participants with microchimerism will undergo additional blood collection at Months 12 18 24 30 and 36 Information will be collected from all participants on health status injury characteristics hospital care blood transfusion details and blood donor characteristics
In this study blood samples will be collected from injured individuals who arrive at the University of California at Davis Medical Center Individuals who receive a blood transfusion as well as a control group of individuals who do not receive a transfusion will be approached to enroll in the study Individuals who agree to participate will have their blood collected at Days 7 14 and 28 and Months 3 and 6 Study researchers will analyze the blood for evidence of microchimerism Participants with microchimerism will undergo additional blood collection at Months 12 18 24 30 and 36 Information will be collected from all participants on health status injury characteristics hospital care blood transfusion details and blood donor characteristics
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL083388 | NIH | None | httpsreporternihgovquickSearchR01HL083388 |