Ignite Creation Date:
2024-05-06 @ 2:59 PM
Last Modification Date:
2024-10-26 @ 1:41 PM
Study NCT ID:
NCT04492540
Status:
COMPLETED
Last Update Posted:
2023-10-06
First Post:
2020-07-27
Brief Title:
Response of Sex Hormones and Different Functions to Exercise and Diet in Elderly Women
Sponsor:
Cairo University
Organization:
Cairo University
Study Overview
Official Title:
Correlation Between Sex Hormones and Different Functions in Response to Aerobic Exercise and MIND Diet in Older Adult Women
Status:
COMPLETED
Status Verified Date:
2023-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
It is an interventional study in which 60 women estimated to enroll according to random allocation and divided into two groups The study group will receive aerobic exercise in addition to diet restriction while the control group will receive diet recommendations the aerobic exercise in form of treadmill training intensity of exercise moderate intensity target heart rate THR will be 50-60 of heart maximum HR MAX time of session 40 min initial 10 min warm up exercise on treadmill in low intensity and active phase 20- 30 min intensity will increase until patient reach to THR then intensity decrease until session will be ended by cooling down phase for 10 min The volunteers will perform exercise 3 times per week for 12 weeks different functions and markers will be measured and sex hormones estradiol testosterone sex hormone binding globin pre and post
Detailed Description:
PURPOSE
to determine the effect of aerobic exercise and diet on sex hormones and different functions and markers and if is there correlation between two factors effect in postmenopausal elderly women
BACKGROUND
Alzheimers disease AD is the most common neurodegenerative disease accounting for more than 50 of all dementia types Its twice more common in females which could be due to increased longevity and sex difference in brain size Estrogen has neurotrophic action in areas involved in memory and cognition Post-menopausal women are at increased risk than their male counterpart Women with Alzheimer have lower endogenous estrogen level which lead to the hypothesis that estrogen could be neuroprotective Estrogen and androgen receptors are widely distributed throughout the brain eg in the cerebral cortex amygdala hypo-thalamus and also in the hippocampus which is important for cognitive functioning There are shown clear associations between sex hormones and activities in memory emotional and rewarding circuits in the brain measured with functional magnetic resonance imaging several significant correlations were found between serum hormone levels and spatial ability High absolute estrogen levels a high estrogentestosterone ratio and increasing levels during estrogen treatment were all associated with lower spatial ability This is in agreement with many previous reports of sex differences where women in general tend to perform worse than men in this specific aspect of cognitive function In menstruating women a deterioration of spatial ability was demonstrated during high levels of circulating estrogen and it was improved during the menstrual phase of the cycle when hormone levels are lowest
HYPOTHESES
There is no correlation between sex hormones and different functions and markers in response to aerobic exercise and diet in elderly postmenopausal women
RESEARCH QUESTION
Is there correlation between sex hormones and different functions and markers in elderly postmenopausal women in response to aerobic exercise and dietary restriction
to determine the effect of aerobic exercise and diet on sex hormones and different functions and markers and if is there correlation between two factors effect in postmenopausal elderly women
BACKGROUND
Alzheimers disease AD is the most common neurodegenerative disease accounting for more than 50 of all dementia types Its twice more common in females which could be due to increased longevity and sex difference in brain size Estrogen has neurotrophic action in areas involved in memory and cognition Post-menopausal women are at increased risk than their male counterpart Women with Alzheimer have lower endogenous estrogen level which lead to the hypothesis that estrogen could be neuroprotective Estrogen and androgen receptors are widely distributed throughout the brain eg in the cerebral cortex amygdala hypo-thalamus and also in the hippocampus which is important for cognitive functioning There are shown clear associations between sex hormones and activities in memory emotional and rewarding circuits in the brain measured with functional magnetic resonance imaging several significant correlations were found between serum hormone levels and spatial ability High absolute estrogen levels a high estrogentestosterone ratio and increasing levels during estrogen treatment were all associated with lower spatial ability This is in agreement with many previous reports of sex differences where women in general tend to perform worse than men in this specific aspect of cognitive function In menstruating women a deterioration of spatial ability was demonstrated during high levels of circulating estrogen and it was improved during the menstrual phase of the cycle when hormone levels are lowest
HYPOTHESES
There is no correlation between sex hormones and different functions and markers in response to aerobic exercise and diet in elderly postmenopausal women
RESEARCH QUESTION
Is there correlation between sex hormones and different functions and markers in elderly postmenopausal women in response to aerobic exercise and dietary restriction
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None