Ignite Creation Date:
2024-05-06 @ 2:58 PM
Last Modification Date:
2024-10-26 @ 1:40 PM
Study NCT ID:
NCT04484558
Status:
UNKNOWN
Last Update Posted:
2020-07-23
First Post:
2020-02-16
Brief Title:
Anxiety and Depression Disorder in Patient Treated With rTPA for Mangment of Acute Ischemic Stroke
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
Anxiety and Depression Disorder in Patient Treated With rTPA for Mangment of Acute Ischemic Stroke
Status:
UNKNOWN
Status Verified Date:
2020-07
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
In fact theWorld Health Organization estimates that 2-3 in general populations of countries across the world tend to be affected by severe mental disorders 1 Thrombolytic therapy seems to be of great importance in achieving better quality of life in ischemic stroke patients who respond to this therapyrTPA
Detailed Description:
There is a substantial body of evidenc suggesting a strong relation between neurotrophic factors and depression and anxiety pathogenesis 28 Brain-derived neurotrophic factor BDNF a member of the neurotrophic family known to regulate neuronal plasticity and survival may play an important role in the pathophysiology of depression and anxiety 39
Different studies indicated patients who were exposed to traumatic events have anxiety comorbidity and lower levels of serum BDNF compared to those without a history of traumatic events 4
BDNF has an antidepressant and anxiolytic effect which suggest that BDNF is implicated in the regulation of anxiety-related behaviors which leads to a valine-to-methionine change in the proBDNF protein was associated with lower activity-dependent secretion of BDNF 5and has been implicated with increased susceptibility to neuropsychiatric disorders including depression anxiety-related dysfunction and bipolar disorder all these studies suggest that BDNF is likely to be an important etiological factor in memory depression and anxiety disorders 610
BDNF arises from a precursor proBDNF which is cleaved to produce the mature protein through the tissue plasminogen activator tPA pathway and represents one mechanism that can regulate the action of BDNFarises from a precursor proBDNF which is cleaved to produce the mature protein through the tissue plasminogen activator tPA pathway and represents one mechanism that can regulate the action of BDNF 7
The purpose of this study is to examine the quality of life after stroke of patients treated with thrombolysis
Different studies indicated patients who were exposed to traumatic events have anxiety comorbidity and lower levels of serum BDNF compared to those without a history of traumatic events 4
BDNF has an antidepressant and anxiolytic effect which suggest that BDNF is implicated in the regulation of anxiety-related behaviors which leads to a valine-to-methionine change in the proBDNF protein was associated with lower activity-dependent secretion of BDNF 5and has been implicated with increased susceptibility to neuropsychiatric disorders including depression anxiety-related dysfunction and bipolar disorder all these studies suggest that BDNF is likely to be an important etiological factor in memory depression and anxiety disorders 610
BDNF arises from a precursor proBDNF which is cleaved to produce the mature protein through the tissue plasminogen activator tPA pathway and represents one mechanism that can regulate the action of BDNFarises from a precursor proBDNF which is cleaved to produce the mature protein through the tissue plasminogen activator tPA pathway and represents one mechanism that can regulate the action of BDNF 7
The purpose of this study is to examine the quality of life after stroke of patients treated with thrombolysis
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
True
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
False
Is an FDA AA801 Violation?:
None