Ignite Creation Date:
2024-05-06 @ 2:58 PM
Last Modification Date:
2024-10-26 @ 1:41 PM
Study NCT ID:
NCT04486105
Status:
UNKNOWN
Last Update Posted:
2020-07-24
First Post:
2020-07-15
Brief Title:
Chronic Sucrose Intake Markers of Health and Biomarker Identification
Sponsor:
Northumbria University
Organization:
Northumbria University
Study Overview
Official Title:
Investigation of Sucrose-induced Metabolic Adaptation and Biomarkers of Chronic Sucrose Intake in Humans Using a Multi-omic Approach
Status:
UNKNOWN
Status Verified Date:
2020-07
Last Known Status:
ACTIVE_NOT_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
With free sugar intake proving to be of a concern within the general public discovery and validation of a new biomarker will allow for more consistent measurement of sucrose intake Furthermore using a multi-omic approach the investigators will identify metabolic perturbations to the metabolome and proteome
Detailed Description:
Excessive free sugar intake is of concern within the general public as intakes have been associated with weight gain and cardiovascular disease Average intakes are over double that of the 5 of total energy intake that is recommended by the Science Advisory Committee on Nutrition but intakes are calculated from observational measures that lack sensitivity and discovery and validation of a new biomarker from biological fluids may allow for more specific measurement and a better understanding of intakedisease relationships Furthermore understanding the biochemistry of sucrose intake will allow the identification of damage occurrence and alternative metabolic pathways as well as novel protein damage that occur with chronic sucrose exposure
This study aims to identify a biomarker of chronic sucrose consumption using metabolite profiling technology The study will be composed of a randomised controlled intervention trial in which participants will be required to consume an amount of sucrose 0-120gd every day for 7 days and provide biofluid samples urine and blood before the initiation during and following the intervention that will undergo metabolic analysis Furthermore participants will have their anthropometrics and dietary intake monitored throughout the study The biomarker will also be validated against the dietary information and correlated with indices of health and sucrose-induced damage The investigators will also monitor the feasibility and acceptability of chronic sucrose intake during the intervention
This study aims to identify a biomarker of chronic sucrose consumption using metabolite profiling technology The study will be composed of a randomised controlled intervention trial in which participants will be required to consume an amount of sucrose 0-120gd every day for 7 days and provide biofluid samples urine and blood before the initiation during and following the intervention that will undergo metabolic analysis Furthermore participants will have their anthropometrics and dietary intake monitored throughout the study The biomarker will also be validated against the dietary information and correlated with indices of health and sucrose-induced damage The investigators will also monitor the feasibility and acceptability of chronic sucrose intake during the intervention
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None