Ignite Creation Date:
2024-05-06 @ 2:57 PM
Last Modification Date:
2024-10-26 @ 1:40 PM
Study NCT ID:
NCT04479813
Status:
COMPLETED
Last Update Posted:
2022-09-29
First Post:
2020-07-16
Brief Title:
Role of Sympathetic Activation in Ischemia Reperfusion Injury
Sponsor:
Royal Perth Hospital
Organization:
Royal Perth Hospital
Study Overview
Official Title:
Role of Sympathetic Activation in Ischemia Reperfusion Injury
Status:
COMPLETED
Status Verified Date:
2022-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study is designed to assess the effect of forearm ischemia-reperfusion injury on sympathetic nerve activity To determine whether reduced sympathetic responsiveness is a contributor to the protective effects of remote ischemic preconditioning In addition it will assess whether pharmacologic inhibition of the sympathetic nervous system can ameliorate ischemia reperfusion injury induced endothelial dysfunction
Detailed Description:
This is a randomized single blind study where subjects will be allocated to undergo one of the 4 protocols Participants will be given placebo or 02mg of Moxonidine to take orally 20 minutes prior to the first endothelial function measurement
This medication acts by reducing the activity of nerves believed to be involved in the conditioning process The placebo pill designed to have no effect will be used as a comparison Comprehensive tests will occur which include Microneurography Endothelial function Blood Sampling Temporary block of arm blood flow and Remote conditioning
This medication acts by reducing the activity of nerves believed to be involved in the conditioning process The placebo pill designed to have no effect will be used as a comparison Comprehensive tests will occur which include Microneurography Endothelial function Blood Sampling Temporary block of arm blood flow and Remote conditioning
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None