Ignite Creation Date:
2024-05-06 @ 2:56 PM
Last Modification Date:
2024-10-26 @ 1:40 PM
Study NCT ID:
NCT04470037
Status:
RECRUITING
Last Update Posted:
2023-08-08
First Post:
2020-05-26
Brief Title:
Multidisciplinary Study of Novel NMDA Modulation for Neurodegenerative Disorder
Sponsor:
China Medical University Hospital
Organization:
China Medical University Hospital
Study Overview
Official Title:
Multidisciplinary Study of Novel NMDA Modulation for Neurodegenerative Disorder
Status:
RECRUITING
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Alzheimers disease AD and Parkinsons disease PD are currently the leading neurodegenerative disorders Considering the fact that aged population is rapidly growing it has become a critical issue to find more effective medications for these two disorders The aim of this project is to examine the effectiveness and safety of DAAOI-P treatment for PD with dementia
Detailed Description:
Alzheimers disease AD and Parkinsons disease PD are currently the leading neurodegenerative disorders Despite some therapeutic benefits from the medications targeting at cholinergic and dopaminergic pathways in AD and PD respectively it remains far away from a satisfied treatment goal DAAOI-P is a D-amino acid oxidase DAAO inhibitor and an agent specific to facilitate NMDA receptor subunit 1 NR1 The investigators have demonstrated that NMDA-enhancement can help PD-D patients The aim of this project is to examine the effectiveness and safety of DAAOI-P treatment for PD with dementia In addition to evaluating clinical treatment response multidisciplinary examinations including electroencephalography transcranial magnetic stimulation magnetic resonance imaging MRI and psychophysical methods to analyze the changes in perceptual sensitivity to faces emotion expressions and biological motion recognition will be arranged to elucidate the underlying mechanism of NMDA modulation in neurodegenerative disorder
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None