Ignite Creation Date:
2024-05-06 @ 2:56 PM
Last Modification Date:
2024-10-26 @ 1:40 PM
Study NCT ID:
NCT04470323
Status:
UNKNOWN
Last Update Posted:
2020-08-06
First Post:
2020-07-12
Brief Title:
Functional Exhaustion of T Cells in COVID19 Patients
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
Functional Exhaustion of T Cells in COVID19 Patients
Status:
UNKNOWN
Status Verified Date:
2020-08
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The primary end-point of our prospective observational study is to count T cells in patients with laboratory-confirmed COVID-19 and healthy controls In addition the expression of T cell exhaustion marker was measured in COVID-19 cases
Detailed Description:
COVID-19 caused by severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 has posed great threat to human health T cells play a critical role in antiviral immunity but their numbers and functional state in COVID-19 patients remain largely unclear The immune response against viral infections depends on the activation of cytotoxic T cells that can clear infection by killing virus-infected cells so boosting the numbers and function of T cells in COVID-19 patients is critical for successful recovery However the factors which might cause the reduction in count and the activation status of T cells in COVID-19 patients remain uninvestigated Thus demonstration of T cell exhaustion during COVID-19 infection suggest that more urgent early intervention may be required in patients with low T lymphocyte counts
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None