Ignite Creation Date:
2024-05-05 @ 5:10 PM
Last Modification Date:
2024-10-26 @ 9:29 AM
Study NCT ID:
NCT00404677
Status:
COMPLETED
Last Update Posted:
2008-01-23
First Post:
2006-11-27
Brief Title:
The Correlation Between Airway Inflammation and Loss of Deep Inhalation Bronchoprotection in Asthmatics
Sponsor:
University of Saskatchewan
Organization:
University of Saskatchewan
Study Overview
Official Title:
The Correlation Between Airway Inflammation and Loss of Deep Inhalation Bronchoprotection in Asthmatics
Status:
COMPLETED
Status Verified Date:
2008-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The loss of deep inhalation bronchoprotection in asthmatic individuals has been shown to be related to the degree of airway hyperresponsiveness a hallmark of asthma In several studies asthmatic individuals with mild airway hyperresponsiveness AHR methacholine PC20 2 mgmL had a difference in methacholine PC20 with and without deep inhalations that averaged 18 doubling methacholine concentrations p00003 Conversely asthmatic individuals with moderate to severe AHR methacholine PC20 2 mgmL had a non-significant difference in methacholine PC20 with and without deep inhalations p009 This loss of deep inhalation bronchoprotection is also now believed to play an important role in the pathogenesis of asthma Airway inflammation is another of the key features of asthma and information on airway inflammation is increasingly being used in the diagnosis and treatment of asthma The level of airway inflammation as measured by fraction of exhaled nitric oxide and sputum eosinophilia has also been shown to be correlated to the level of airway hyperresponsiveness as measured by methacholine PC20 In addition glucocorticoids have been shown to decrease airway hyperresponsiveness further suggesting that these two phenomena airway inflammation and airway hyperresponsiveness are related We therefore suggest that the degree of airway inflammation is related to the loss of deep inhalation bronchoprotection and expect there to be a negative correlation between the degree of deep inhalation bronchoprotection and airway inflammation
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| BIO-REB 06-92 | None | None | None |