Ignite Creation Date:
2024-05-05 @ 11:19 AM
Last Modification Date:
2024-10-26 @ 9:04 AM
Study NCT ID:
NCT00005250
Status:
COMPLETED
Last Update Posted:
2016-05-13
First Post:
2000-05-25
Brief Title:
Linkage Study of Long QT Syndrome In An Amish Kindred
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Heart Lung and Blood Institute NHLBI
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2001-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To screen by electrocardiography the entire population of 1400 individuals in seven Amish Mennonite communities in order to perform genetic linkage studies of long QT syndrome LQTS
Detailed Description:
BACKGROUND
LQTS is a severe heart disorder leading to sudden death due to ventricular tachycardia or ventricular fibrillation The syndrome segregated as a Mendelian recessive in the highly inbred population under study and resulted in the sudden death of several members of the population
DESIGN NARRATIVE
The entire population was screened to identify cases of LQTS In addition 29 obligate heterozygotes were studied by 24-hour Holter monitoring to determine whether these gene carriers had any subtle phenotypes The data were subjected to complex segregation and linkage analysis to establish the mode of inheritance and penetrance of LQTS
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
LQTS is a severe heart disorder leading to sudden death due to ventricular tachycardia or ventricular fibrillation The syndrome segregated as a Mendelian recessive in the highly inbred population under study and resulted in the sudden death of several members of the population
DESIGN NARRATIVE
The entire population was screened to identify cases of LQTS In addition 29 obligate heterozygotes were studied by 24-hour Holter monitoring to determine whether these gene carriers had any subtle phenotypes The data were subjected to complex segregation and linkage analysis to establish the mode of inheritance and penetrance of LQTS
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL041035 | NIH | None | httpsreporternihgovquickSearchR01HL041035 |