Ignite Creation Date:
2024-05-06 @ 2:55 PM
Last Modification Date:
2024-10-26 @ 1:39 PM
Study NCT ID:
NCT04465123
Status:
UNKNOWN
Last Update Posted:
2020-08-18
First Post:
2020-07-06
Brief Title:
Early Sequential Nephron Blockade in Acute Heart Failure Patients A Randomised Controlled Study
Sponsor:
Chiang Mai University
Organization:
Chiang Mai University
Study Overview
Official Title:
Furosemide With Early Sequential Nephron Blockade Versus Furosemide Alone in Acute Heart Failure Patients With Furosemide-guided Diuretic Resistance A Double-blinded Randomized Placebo-controlled Study
Status:
UNKNOWN
Status Verified Date:
2020-08
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
NEB-HF
Brief Summary:
This study aims to demonstrate the efficacy of sequential nephron blockade by adding hydrochlorothiazide or spironolactone on intravenous furosemide compared to intravenous furosemide alone in the treatments of volume overload in patients with acute heart failure who have diuretic resistance from furosemide stress test
Detailed Description:
This study is a randomised double-blinded double-dummy placebo-controlled study to demonstrate the efficacy of oral hydrochlorothiazide or spironolactone in combination with intravenous furosemide compared to intravenous furosemide in combination with placebo Dosage of intravenous furosemide will be adjusted according to pre-defined protocol The primary outcome is urine volume during 72 hours after randomisation
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None