Ignite Creation Date:
2024-05-06 @ 2:55 PM
Last Modification Date:
2024-10-26 @ 1:39 PM
Study NCT ID:
NCT04465539
Status:
COMPLETED
Last Update Posted:
2024-05-01
First Post:
2020-07-06
Brief Title:
The Potential Therapeutic Role of Hydroxyethyl Starch and Hydrocortisone in Acute Aluminum Phosphide Poisoning
Sponsor:
Tanta University
Organization:
Tanta University
Study Overview
Official Title:
The Potential Therapeutic Role of Hydroxyethyl Starch and Hydrocortisone in Acute Aluminum Phosphide Poisoning A Randamized Controlled Clinical Trial
Status:
COMPLETED
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Aluminum phosphide ALP is a widely used fumigant due to its efficiency as pesticides It is available as tablets of Celphos Alphos or Quickphos which are known as rice tablets Each tablet weights 3 grams and contains 56 ALP and 44 of aluminum carbonate and paraffin The incidence of ALP poisoning increased steadily specially in developing countries ALP poisoning is considered to be one of the major causes of suicidal poisoning owing to its wide accessibility and low cost However accidental poisoning may occur during occupational exposure
Detailed Description:
Aluminum phosphide ALP is a widely used fumigant due to its efficiency as pesticides It is available as tablets of Celphos Alphos or Quickphos which are known as rice tablets Each tablet weights 3 grams and contains 56 ALP and 44 of aluminum carbonate and paraffin The incidence of ALP poisoning increased steadily specially in developing countries ALP poisoning is considered to be one of the major causes of suicidal poisoning owing to its wide accessibility and low cost However accidental poisoning may occur during occupational exposure
Signs and symptoms of acute AlP poisoning include gastrointestinal cardiovascular hepatic renal and neurologic 1 Ingestion of ALP causes mild gastrointestinal GIT manifestations as nausea vomiting abdominal pain in addition to chest tightness hypotension headache and dizziness In severe cases GIT hemorrhage shock severe metabolic acidosis cardiac arrhythmia convulsions and coma may occur Later signs of hepatic damage and renal insufficiency may develop
Death usually occurs in 30-70 of cases within the first 24 hours resulting from refractory cardiogenic shock cardiac arrhythmia severe hypotension and metabolic acidosisThe main causes of cardiovascular collapse are increase capillary permeability insufficient systemic vasoconstriction with low ventricular ejection fraction On autopsy examinations point to extravasation of fluid into the third space
The management is exclusively supportive as gastric lavage with KMnO4 solution treatment of hypotension and acidosis in view of the fact that there is no specific antidote available
Signs and symptoms of acute AlP poisoning include gastrointestinal cardiovascular hepatic renal and neurologic 1 Ingestion of ALP causes mild gastrointestinal GIT manifestations as nausea vomiting abdominal pain in addition to chest tightness hypotension headache and dizziness In severe cases GIT hemorrhage shock severe metabolic acidosis cardiac arrhythmia convulsions and coma may occur Later signs of hepatic damage and renal insufficiency may develop
Death usually occurs in 30-70 of cases within the first 24 hours resulting from refractory cardiogenic shock cardiac arrhythmia severe hypotension and metabolic acidosisThe main causes of cardiovascular collapse are increase capillary permeability insufficient systemic vasoconstriction with low ventricular ejection fraction On autopsy examinations point to extravasation of fluid into the third space
The management is exclusively supportive as gastric lavage with KMnO4 solution treatment of hypotension and acidosis in view of the fact that there is no specific antidote available
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None