Ignite Creation Date:
2024-05-05 @ 5:09 PM
Last Modification Date:
2024-10-26 @ 9:28 AM
Study NCT ID:
NCT00396344
Status:
COMPLETED
Last Update Posted:
2008-05-09
First Post:
2006-11-03
Brief Title:
Cortisol Control of Human Inflammatory Responses to Endotoxin
Sponsor:
Dartmouth-Hitchcock Medical Center
Organization:
Dartmouth-Hitchcock Medical Center
Study Overview
Official Title:
The Effect of Glucocorticoid Pre-Treatment on the Systemic Cytokine Response to Endotoxin in Human Volunteers
Status:
COMPLETED
Status Verified Date:
2008-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of the research is to study a common and dangerous medical condition called septic shock that often occurs in critically ill patients In order to learn about septic shock in humans we will administer a substance called endotoxin to participants in this study Endotoxin causes a temporary period of inflammation in the human body a brief virtual infection This is an established method for the investigation of inflammation properties We are interested in how the natural hormone cortisol can affect the human response to endotoxin We know that when cortisol is given at the same time as endotoxin it can decrease the inflammation that occurs due to endotoxin In this study we will test whether or not cortisol when given the day before the endotoxin will work to change the inflammation that occurs due to endotoxin In order to test this two-thirds of the study participants will receive cortisol on the day before they receive the endotoxin and one-third of the study participants will receive a placebo no medication before the endotoxin
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| NIHAIO51547 | None | None | None |