Ignite Creation Date:
2024-05-05 @ 5:09 PM
Last Modification Date:
2024-10-26 @ 9:28 AM
Study NCT ID:
NCT00390819
Status:
UNKNOWN
Last Update Posted:
2006-10-20
First Post:
2006-10-19
Brief Title:
Epidemiology of Community Acquired Pneumonia in North Israel
Sponsor:
HaEmek Medical Center Israel
Organization:
HaEmek Medical Center Israel
Study Overview
Official Title:
Epidemiology of Community Acquired Pneumonia in North Israel
Status:
UNKNOWN
Status Verified Date:
2006-10
Last Known Status:
NOT_YET_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Pneumonia in general and CAP in particular is considered as one of the most common bacterial infections associated with high rates of morbidity and mortality and is highly significant economically since all respiratory infections and pneumonia especially cause about 80 of antimicrobials use in the community The high frequency of respiratory infections and the excessive use of antimicrobials are major contributors to the development of pathogens resistant to antimicrobials In addition in CAP almost all patients are treated empirically without identification of causing pathogen
Aim of study To identify common pathogens causing CAP in hospitalized patients in north Israel
Aim of study To identify common pathogens causing CAP in hospitalized patients in north Israel
Detailed Description:
Pneumonia in general and CAP in particular is considered as one of the most common bacterial infections associated with high rates of morbidity and mortality
CAP is highly significant economically since all respiratory infections and pneumonia especially cause about 80 of antimicrobials use in the community The high frequency of respiratory infections and the excessive use of antimicrobials are major contributors to the development of pathogens resistant to antimicrobials In addition in CAP almost all patients are treated empirically without identification of causing pathogen
CAP is divided to two principal groups Bacterial CAP and Atypical CAP Since pathogens are different treatment approach is also different The main obstacle is absence of adequate diagnostic immediate and cheap tools to enable identifying pathogen and hence treatment is not always appropriate Giving the right therapy at the right time is of major importance since early start of correct treatment is linked to morbidity and mortality of patients For prescribing appropriate empiric therapy knowing the epidemiology of CAP ie the frequent causing pathogens according to age groups and other demographic characteristics is essential
Unfortunately except one study conducted 10 years ago by Dr Liberman from Soroka Medical Center there is no characteristic information regarding causing pathogens Lacking this data might result in selecting inadequate treatment
Material Methods
We should enroll about 300 patients hospitalized in HaEmek Medical Center with the diagnosis of CAP in order to make the study results statistically significant
In addition to demographic and clinical data following tests will be performed
1 Blood cultures
2 Sputum
3 PCR - throat culture to the following pathogens
Mycoplasma pneumoniae
Chlamydia pneumoniae
Legionella
Adenovirus
Influenza A
Influenza B
RSV
Metapneumovirus
Parainfluenza
Pneumococcal antigen in urine
CAP is highly significant economically since all respiratory infections and pneumonia especially cause about 80 of antimicrobials use in the community The high frequency of respiratory infections and the excessive use of antimicrobials are major contributors to the development of pathogens resistant to antimicrobials In addition in CAP almost all patients are treated empirically without identification of causing pathogen
CAP is divided to two principal groups Bacterial CAP and Atypical CAP Since pathogens are different treatment approach is also different The main obstacle is absence of adequate diagnostic immediate and cheap tools to enable identifying pathogen and hence treatment is not always appropriate Giving the right therapy at the right time is of major importance since early start of correct treatment is linked to morbidity and mortality of patients For prescribing appropriate empiric therapy knowing the epidemiology of CAP ie the frequent causing pathogens according to age groups and other demographic characteristics is essential
Unfortunately except one study conducted 10 years ago by Dr Liberman from Soroka Medical Center there is no characteristic information regarding causing pathogens Lacking this data might result in selecting inadequate treatment
Material Methods
We should enroll about 300 patients hospitalized in HaEmek Medical Center with the diagnosis of CAP in order to make the study results statistically significant
In addition to demographic and clinical data following tests will be performed
1 Blood cultures
2 Sputum
3 PCR - throat culture to the following pathogens
Mycoplasma pneumoniae
Chlamydia pneumoniae
Legionella
Adenovirus
Influenza A
Influenza B
RSV
Metapneumovirus
Parainfluenza
Pneumococcal antigen in urine
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None