Ignite Creation Date:
2024-05-06 @ 2:51 PM
Last Modification Date:
2024-10-26 @ 1:38 PM
Study NCT ID:
NCT04443491
Status:
COMPLETED
Last Update Posted:
2020-06-23
First Post:
2020-06-01
Brief Title:
Comparison of Esophageal and Central Venous Pressure for Estimating Transpulmonary Pressure Changes
Sponsor:
University of Siena
Organization:
University of Siena
Study Overview
Official Title:
Estimating the Transpulmonary Pressure From the Central Venous Pressure in Mechanically Ventilated Patients With Respiratory Failure
Status:
COMPLETED
Status Verified Date:
2020-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
PPLproject
Brief Summary:
Central venous pressure CVP is characterized by a low-frequency pleural-dependent as well as a high-frequency cardiac pulsatile component The aim of the study is to compare the low-frequency component of CVP with the esophageal pressure Pes as surrogate of pleural pressure to estimate trans-pulmonary pressure PL
Detailed Description:
The investigators will enroll mechanically ventilated patients admitted to the intensive care unit with the diagnosis of respiratory failure monitored with a dedicated nasogastric catheter and a central venous catheter for measuring Pes and CVP respectively Electrocardiogram trace Pes CVP and airway pressure Paw will be recorded at the end of inspiratory and expiratory pauses The CVP waveforms will be analyzed off-line using a dedicated low-pass digital filter to obtain the low-frequency component of CVP filtered CVP fCVP Paw Pes and fCVP will be used to calculate PL using transpulmonary driving pressure formula PL-Pes and PL-fCVP respectively The PL values obtained with fCVP and Pes will be compared to assess the correlation of the two methods
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None