Ignite Creation Date:
2024-05-06 @ 2:49 PM
Last Modification Date:
2024-10-26 @ 1:37 PM
Study NCT ID:
NCT04431661
Status:
TERMINATED
Last Update Posted:
2023-03-13
First Post:
2020-06-11
Brief Title:
CAOCT Intra CoronAry Optical Computerized Tomography in out-of Hospital Cardiac Arrest Patients
Sponsor:
Ceric Sàrl
Organization:
Ceric Sàrl
Study Overview
Official Title:
CAOCT Study is a Prospective Multi-centre Single Cohort Diagnostic Accuracy Study Planned to Include 131 Patients in About 3 European Countries After Successful Return of Spontaneous Circulation After Out of Hospital Cardiac Arrest
Status:
TERMINATED
Status Verified Date:
2023-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Low patient recruitment rate and change of hopsital procedures for handling cardiac arrest patients during emergency
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Out-of-hospital cardiac arrest OHCA is a leading cause of sudden death in Europe and the United States Mortality is currently close to 40 among those patients who had been successfully resuscitated after OHCA associated with ventricular fibrillation or pulseless ventricular tachycardia Coronary artery disease is observed in up to 70 of patients with OHCA and immediate coronary angiography Current European and American guidelines recommend immediate coronary angiography with primary angioplasty in OHCA patients with ST-segment elevation on ECG after successful resuscitation Furthermore the identification of the culprit lesion by coronary angiography among patients with an acute coronary syndrome ACS and no OHCA is challenging In a recent cardiac magnetic resonance study Heitner et al found that in almost half of the patients with non-ST segment elevation ACS the culprit lesion was not properly detected or identified by coronary angiography In the Coronary Angiography after cardiac arrest COACT trial a randomized controlled trial comparing immediate versus delayed coronary angiography after OHCA in patients without ST segment elevation on ECG some degree of coronary artery disease was found in 645 of the patients in the immediate angiography group and an unstable coronary lesion was identified in only 136 of the patients However in survivors of OHCA without ST segment elevation on ECG the use of intra coronary optical computerized tomography OCT led to identification of plaque rupture 27 plaque erosion 36 and coronary thrombosis 59 undetected on angiography There is hence a clear need to improve causality diagnosis among patients resuscitated after OHCA and without ST segment elevation on ECG and in the case of coronary artery disease detection to better identify the culprit vessellesion ultimately leading to a targeted treatment These are the reasons why we have designed a prospective multi-centre single cohort diagnostic accuracy study to better explore the incidence of a true ACS among OHCA survivors and to evaluate the accuracy of angiography to detect the culprit lesion when compared to OCT
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None